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Invitrogen
Hemoglobin gamma-1,2 Recombinant Rabbit Monoclonal Antibody (JM84-10)
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FIGURE: 1 / 6
Hemoglobin gamma-1,2 Antibody (MA5-32603) in ICC/IF
Immunocytochemical analysis of Fetal Hemoglobin in PC-12 cells using a Fetal Hemoglobin Monoclonal antibody (Product # MA5-32603) as seen in red. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Product Details
MA5-32603
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JM84-10
Immunogen
Synthetic peptide within Human HBG1/2 aa 2-45
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2809880
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Hemorrhage of cells from an Rh+ fetus into the circulation of an Rh- mother may result in the formation of Rh-reactive antibodies in the mother. Rh hemolytic anemia in a subsequent Rh+ fetus may result from placental transfer of antibodies formed in the mother to the fetus. Although the volume of fetal erythrocytes found in the maternal circulation during pregnancy and immediately post-partum is reported to be small and of uncertain clinical significance in many cases, substantial hemorrhage may result from a number of causes including fetal or maternal trauma and placental defects. Erythrocytes containing fetal hemoglobin may be found in individuals of any age, but with lower amounts of fetal hemoglobin compared to fetal red cells. These cells have been termed F cells. High levels of F cells may also exist in adults with a heterogeneous group of genetic disorders of uncertain etiology, referred to as Hereditary Persistence of Fetal Hemoglobin. Other clinical conditions causing significant levels of anemia may also result in elevated levels of F cells. Several clinical conditions have been described with increased levels of F cells. These conditions include hereditary anemic diseases such as sickle cell anemia and thalassemia major.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A-gamma globin; abnormal hemoglobin; G-gamma globin Paulinia; gamma A hemoglobin; gamma globin; Gamma-1-globin; Gamma-2-globin; Hb F Agamma; Hb F Ggamma; Hemoglobin gamma-1 chain; Hemoglobin gamma-2 chain; Hemoglobin gamma-A chain; Hemoglobin gamma-G chain; Hemoglobin subunit gamma-1; Hemoglobin subunit gamma-2; hemoglobin, gamma A; hemoglobin, gamma G; hemoglobin, gamma, regulator of; methemoglobin
Gene Aliases: HBG-T1; HBG-T2; HBG1; HBG2; HBGA; HBGR; HSGGL1; PRO2979; TNCY
UniProt ID: (Human) P69891, (Human) P69892
Entrez Gene ID: (Human) 3047, (Human) 3048
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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