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NeoBiotechnologies
Heparan Sulfate Proteoglycan (Large)/Perlecan Monoclonal Antibody (A7L6)
Product Details
3339-RTM1-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Fish,
Human,
Mouse,
Non-human primate,
Pig
Host/Isotype
Rat
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
A7L6
Immunogen
Murine EHS laminin preparation
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Target Information
Perlecan is a major heparan-sulfate proteoglycan (HSPG) found within all basement membranes and cell surfaces. Because of its strategic location and ability to store and protect growth factors, perlecan has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Basement membrane-specific heparan sulfate proteoglycan core protein; endorepellin (domain V region); HSPG; Perlecan; perlecan proteoglycan; PLC; RP11-132G19.2
Gene Aliases: AI852380; BOS_2497; HSPG; HSPG2; Pcn; per; PLC; PRCAN; SJA; SJS; SJS1
UniProt ID: (Human) P98160, (Mouse) Q05793
Entrez Gene ID: (Human) 3339, (Bovine) 444872, (Mouse) 15530
retinoid metabolic process
angiogenesis
glycosaminoglycan biosynthetic process
glycosaminoglycan catabolic process
extracellular matrix disassembly
extracellular matrix organization
glycosaminoglycan metabolic process
lipoprotein metabolic process
cellular protein metabolic process
endochondral ossification
chondrocyte differentiation
brain development
protein localization
embryonic skeletal system morphogenesis
cardiac muscle tissue development
cartilage development involved in endochondral bone morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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