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Invitrogen
Hex Polyclonal Antibody
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Product Details
PA5-113635
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the c terminal region of mouse Hhex (aa 211-260).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2884150
Product Specific Information
Immunogen sequence: SLDTSCEQGQ DLPSEQNKGA SLDRSQCSPS PASQEDPDSE ISEDSDQEVD
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 85%; Dog: 86%; Guinea Pig: 92%; Horse: 85%; Human: 86%; Mouse: 100%; Rabbit: 86%; Rat: 86%
Target Information
HHEX is a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. Establishes anterior identity at two levels 1) acts early to enhance canonical WNT-signaling by repressing expression of TLE4 and 2) acts later to inhibit NODAL-signaling by directly targeting NODAL.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hematopoietically expressed homeobox, related sequence 2; Hematopoietically-expressed homeobox protein Hhex; homeobox; Homeobox protein HEX; Homeobox protein PRH; mHex; Proline-rich homeodomain protein
Gene Aliases: Hex; Hex1; Hhex; Hhex-rs2; Prh; Prhx
UniProt ID: (Mouse) P43120
Entrez Gene ID: (Mouse) 15242
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
eukaryotic initiation factor 4E binding
DNA binding, bending
protein homodimerization activity
sequence-specific DNA binding
transcription regulatory region DNA binding
repressing transcription factor binding
HMG box domain binding
negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
in utero embryonic development
liver development
morphogenesis of an epithelium
myeloid leukocyte differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
mRNA export from nucleus
signal transduction
Notch signaling pathway
multicellular organism development
endoderm development
cell proliferation
organ morphogenesis
anterior/posterior pattern specification
Wnt signaling pathway
negative regulation of angiogenesis
poly(A)+ mRNA export from nucleus
interkinetic nuclear migration
hemopoiesis
cell differentiation
positive regulation of Wnt signaling pathway
B cell differentiation
thyroid gland development
forebrain development
negative regulation of vascular endothelial growth factor receptor signaling pathway
pancreas development
protein localization to nucleus
embryonic heart tube development
multicellular organism growth
regulation of cell proliferation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
tissue morphogenesis
forebrain morphogenesis
primary lung bud formation
common bile duct development
gall bladder development
hepatic duct development
hepatoblast differentiation
hepatocyte differentiation
DNA conformation change
primitive streak formation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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