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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • HK2 Antibodies

          Proteintech

          Hexokinase 2 Polyclonal Antibody

          212 References
          View all (22) HK2 antibodies

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          Cite Hexokinase 2 Polyclonal Antibody

          • Antibody Testing Data (11)
          Hexokinase 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          Hexokinase 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 11

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          Hexokinase 2 Antibody (22029-1-AP) in IHC (P)

          Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using (Product # 22029-1-AP) (Hexokinase 2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Hexokinase 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Hexokinase 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Hexokinase 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Hexokinase 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Hexokinase 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Hexokinase 2 Antibody in Western Blot (WB)
          Hexokinase 2 Antibody in Western Blot (WB)
          Hexokinase 2 Antibody in Western Blot (WB)
          Hexokinase 2 Antibody in Western Blot (WB)
          Hexokinase 2 Antibody in Western Blot (WB)
          Hexokinase 2 Antibody in Immunoprecipitation (IP)

          Product Details

          22029-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          View 162 publications 162 publications

          Immunohistochemistry (IHC)

          -
          View 32 publications 32 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:20-1:200
          -

          Immunocytochemistry (ICC/IF)

          -
          View 10 publications 10 publications

          Immunoprecipitation (IP)

          0.5-4.0 µg
          View 5 publications 5 publications

          Miscellaneous PubMed (MISC)

          -
          View 1 publication 1 publication

          Not applicable (N/A)

          -
          View 2 publications 2 publications
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Human, Mouse, Pig, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Hexokinase 2 Fusion Protein Ag16895 (568-917 aa encoded by BC021116)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.34 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: HGTGDELFD HIVQCIADFL EYMGMKGVSL PLGFTFSFPC QQNSLDESIL LKWTKGFKAS GCEGEDVVTL LKEAIHRREE FDLDVVAVVN DTVGTMMTCG FEDPHCEVGL IVGTGSNACY MEEMRNVELV EGEEGRMCVN MEWGAFGDNG CLDDFRTEFD VAVDELSLNP GKQRFEKMIS GMYLGEIVRN ILIDFTKRGL LFRGRISERL KTRGIFETKF LSQIESDCLA LLQVRAILQH LGLESTCDDS IIVKEVCTVV ARRAAQLCGA GMAAVVDRIR ENRGLDALKV TVGVDGTLYK LHPHFAKVMH ETVKDLAPKC DVSFLQSEDG SGKGAALITA VACRIREAGQ R (568-917 aa encoded by BC021116)

          Target Information

          In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase activity is involved in the first step in several metabolic pathways including phosphorylation of glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Hexokinase is an allosteric enzyme inhibited by its product GLC-6-P. Hexokinase 2 is the predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: DKFZp686M1669; Hexokinase; Hexokinase type II; Hexokinase-2; hexokinase-2 muscle; hexokinase-2, muscle; Hexokinase-B; HK II; Muscle form hexokinase; OTTHUMP00000202738

          View more View less

          Gene Aliases: AI642394; HK2; HKII; HXK2

          View more View less

          UniProt ID: (Human) P52789, (Mouse) O08528, (Rat) P27881

          View more View less

          Entrez Gene ID: (Human) 3099, (Mouse) 15277, (Rat) 25059

          View more View less

          Function(s)
          glucokinase activity hexokinase activity protein binding ATP binding glucose binding fructokinase activity mannokinase activity nucleotide binding catalytic activity kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor
          Process(es)
          cellular glucose homeostasis response to ischemia glycolytic process lactation apoptotic mitochondrial changes glucose transport negative regulation of mitochondrial membrane permeability regulation of glucose import carbohydrate phosphorylation glucose 6-phosphate metabolic process canonical glycolysis establishment of protein localization to mitochondrion maintenance of protein location in mitochondrion positive regulation of mitophagy in response to mitochondrial depolarization negative regulation of reactive oxygen species metabolic process carbohydrate metabolic process glucose metabolic process metabolic process phosphorylation glucose catabolic process
          It has to be done as per old AB suggested Products section.
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