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Invitrogen
Histone Core Polyclonal Antibody
Product Details
PA1-28375
Product Specifications
Species Reactivity
Bovine
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Intact calf histone core - rRNA complex.
Conjugate
Form
Liquid
Concentration
2.42 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1957612
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The histone core is an integral component of chromatin structure, consisting of an octamer of core histones: H2A, H2B, H3, and H4. Each nucleosome unit contains two copies of each of these histones, forming a structural foundation around which approximately 147 base pairs of DNA are wrapped. The histone octamer is organized with an (H3-H4)2 tetramer at its core, flanked by two H2A-H2B dimers. This highly conserved structure not only facilitates DNA compaction but also plays a critical role in regulating gene expression through various post-translational modifications, such as acetylation, methylation, and phosphorylation. These modifications can alter chromatin dynamics and accessibility, impacting processes such as transcription, replication, and DNA repair. The presence of specific histone variants further adds to the epigenetic complexity and regulation of the genome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: core histone macro-H2A.1; H4.1; Histone H2B type 1; histone H2B type 2-E; Histone H3.3; Histone H4
Gene Aliases: BOS_15646; BOS_21303; BOS_2955; BOS_8141; H3-3A; H3-3B; H3F3A; H3F3B
UniProt ID: (Bovine) P62808, (Bovine) Q5E9F8, (Bovine) P62803
Entrez Gene ID: (Bovine) 532990, (Bovine) 615043, (Bovine) 519934, (Bovine) 326601, (Bovine) 280691
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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