Product References
Adenosine Methylation Level of miR-125a-5p Promotes Anti-PD-1 Therapy Escape through the Regulation of IGSF11/VSIG3 Expression.
Cancers
Bougras-Cartron G,Nadaradjane A,Joalland MP,Lalier-Bretaudeau L,Raimbourg J,Cartron PF
39-0600 was used in Western Blot to provide a biomarker (m6A-miR-125a-5p level) and two therapeutic solutions (anti-IGSF11 antibody and METTL3 inhibitor) that could potentially address the anti-PD1 therapy failure in the context of precision and personalized medicine.
Wed Jun 14 00:00:00 UTC 2023
The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion.
Cell communication and signaling : CCS
Gélabert C,Papoutsoglou P,Golán I,Ahlström E,Ameur A,Heldin CH,Caja L,Moustakas A
39-0600 was used in RNA Immunoprecipitation to investigate the mechanism of action and biological role of Transforming growth factor β (TGFβ) signaling via Smad proteins in cancer.
Mon Oct 02 00:00:00 UTC 2023
RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function.
Genome biology
Shi B,Zhang J,Heng J,Gong J,Zhang T,Li P,Sun BF,Yang Y,Zhang N,Zhao YL,Wang HL,Liu F,Zhang QC,Yang YG
39-0600 was used in Western Blotting to establish the global map of four nucleotide-based mRNA structures by icSHAPE during zebrafish early embryogenesis.
Mon May 18 00:00:00 UTC 2020
A Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis.
Cell
Dai P,Wang X,Gou LT,Li ZT,Wen Z,Chen ZG,Hua MM,Zhong A,Wang L,Su H,Wan H,Qian K,Liao L,Li J,Tian B,Li D,Fu XD,Shi HJ,Zhou Y,Liu MF
39-0600 was used in Immunohistochemistry to determine that the same machinery is responsible for mRNA elimination during late spermiogenesis is responsible for activating translation of a subset of spermiogenic mRNAs to coordinate with morphological transformation into spermatozoa.
Thu Dec 12 00:00:00 UTC 2019
Abemaciclib Is Effective Against Pancreatic Cancer Cells and Synergizes with HuR and YAP1 Inhibition.
Molecular cancer research : MCR
Dhir T,Schultz CW,Jain A,Brown SZ,Haber A,Goetz A,Xi C,Su GH,Xu L,Posey J,Jiang W,Yeo CJ,Golan T,Pishvaian MJ,Brody JR
39-0600 was used in Western Blotting to evaluate the efficacy of abemaciclib in pre-clinical pancreatic ductal adenocarcinomas (PDAC) models in vitro and in vivo and explore its mechanism of action, and screened for potential synergistic combinations.
Tue Oct 01 00:00:00 UTC 2019
DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions.
Cell reports
Zagore LL,Sweet TJ,Hannigan MM,Weyn-Vanhentenryck SM,Jobava R,Hatzoglou M,Zhang C,Licatalosi DD
39-0600 was used in Immunoprecipitation to reveal a mechanism for DAZL-RNA binding and illustrate that DAZL functions as a master regulator of a post-transcriptional mRNA program essential for germ cell survival.
Tue Oct 30 00:00:00 UTC 2018
ALS-associated mutant FUS inhibits macroautophagy which is restored by overexpression of Rab1.
Cell death discovery
Soo KY,Sultana J,King AE,Atkinson R,Warraich ST,Sundaramoorthy V,Blair I,Farg MA,Atkin JD
Published figure using HuR monoclonal antibody (Product # 39-0600) in Immunofluorescence
Tue Aug 23 00:00:00 UTC 2016
A cytoplasmic RNA virus generates functional viral small RNAs and regulates viral IRES activity in mammalian cells.
Nucleic acids research
Weng KF,Hung CT,Hsieh PT,Li ML,Chen GW,Kung YA,Huang PN,Kuo RL,Chen LL,Lin JY,Wang RY,Chen SJ,Tang P,Horng JT,Huang HI,Wang JR,Ojcius DM,Brewer G,Shih SR
39-0600 was used in western blot to examine the generation and function of small RNAs from cytoplasmic RNA viruses
Mon Nov 10 00:00:00 UTC 2014
Welander distal myopathy is caused by a mutation in the RNA-binding protein TIA1.
Annals of neurology
Hackman P,Sarparanta J,Lehtinen S,Vihola A,Evilä A,Jonson PH,Luque H,Kere J,Screen M,Chinnery PF,Åhlberg G,Edström L,Udd B
39-0600 was used in immunohistochemistry to study the causative role of TIA RNA-binding protein mutation in Welander distal myopathy.
Mon Apr 01 00:00:00 UTC 2013
ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation.
PloS one
Walker AK,Soo KY,Sundaramoorthy V,Parakh S,Ma Y,Farg MA,Wallace RH,Crouch PJ,Turner BJ,Horne MK,Atkin JD
39-0600 was used in immunocytochemistry to present evidence that ER stress contributes to TDP-43-mediated disease.
Wed Dec 17 00:00:00 UTC 2014
ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation.
PloS one
Walker AK,Soo KY,Sundaramoorthy V,Parakh S,Ma Y,Farg MA,Wallace RH,Crouch PJ,Turner BJ,Horne MK,Atkin JD
39-0600 was used in immunocytochemistry to present evidence that ER stress contributes to TDP-43-mediated disease.
Wed Dec 17 00:00:00 UTC 2014
ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation.
PloS one
Walker AK,Soo KY,Sundaramoorthy V,Parakh S,Ma Y,Farg MA,Wallace RH,Crouch PJ,Turner BJ,Horne MK,Atkin JD
39-0600 was used in immunocytochemistry to present evidence that ER stress contributes to TDP-43-mediated disease.
Wed Dec 17 00:00:00 UTC 2014
Expression of HuR, COX-2, and survivin in lung cancers; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous cell carcinomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Kim GY,Lim SJ,Kim YW
39-0600 was used in Immunohistochemistry to evaluate HuR, COX-2, and survivin expression and their correlations in primary adenocarcinomas and squamous cell carcinomas in human lung tissue.
Sat Oct 01 00:00:00 UTC 2011
Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs.
PloS one
Markus MA,Marques FZ,Morris BJ
39-0600 was used in immunocytochemistry and western blot to report that resveratrol modulates alternative splicing in a target-specific manner.
Mon Apr 23 00:00:00 UTC 2012
BRCA1-IRIS overexpression abrogates UV-induced p38MAPK/p53 and promotes proliferation of damaged cells.
Oncogene
Chock K,Allison JM,Elshamy WM
39-0600 was used in immunoprecipitation and western blot to study the regulation of the p38MAPK-p53-WIP1 pathway by BRCA1-IRIS in stressed and cancer cells
Thu Sep 23 00:00:00 UTC 2010
Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain.
Journal of neurochemistry
Tiruchinapalli DM,Caron MG,Keene JD
39-0600 was used in Western Blotting to study the dendritic localisation of HuR and HuD RNA-binding proteins and their association with neuronal mRNAs following these two paradigms of seizure and cocaine treatment.
Mon Dec 01 00:00:00 UTC 2008
Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression.
Cancer research
Denkert C,Weichert W,Pest S,Koch I,Licht D,Köbel M,Reles A,Sehouli J,Dietel M,Hauptmann S
Thu Jan 01 00:00:00 UTC 2004
Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression.
Cancer research
Denkert C,Weichert W,Pest S,Koch I,Licht D,Köbel M,Reles A,Sehouli J,Dietel M,Hauptmann S
Thu Jan 01 00:00:00 UTC 2004
HuR binding to cytoplasmic mRNA is perturbed by heat shock.
Proceedings of the National Academy of Sciences of the United States of America
Gallouzi IE,Brennan CM,Stenberg MG,Swanson MS,Eversole A,Maizels N,Steitz JA
Tue Mar 28 00:00:00 UTC 2000
HuR binding to cytoplasmic mRNA is perturbed by heat shock.
Proceedings of the National Academy of Sciences of the United States of America
Gallouzi IE,Brennan CM,Stenberg MG,Swanson MS,Eversole A,Maizels N,Steitz JA
Tue Mar 28 00:00:00 UTC 2000
HuR binding to cytoplasmic mRNA is perturbed by heat shock.
Proceedings of the National Academy of Sciences of the United States of America
Gallouzi IE,Brennan CM,Stenberg MG,Swanson MS,Eversole A,Maizels N,Steitz JA
Tue Mar 28 00:00:00 UTC 2000
HuR binding to cytoplasmic mRNA is perturbed by heat shock.
Proceedings of the National Academy of Sciences of the United States of America
Gallouzi IE,Brennan CM,Stenberg MG,Swanson MS,Eversole A,Maizels N,Steitz JA
Tue Mar 28 00:00:00 UTC 2000
HuR binding to cytoplasmic mRNA is perturbed by heat shock.
Proceedings of the National Academy of Sciences of the United States of America
Gallouzi IE,Brennan CM,Stenberg MG,Swanson MS,Eversole A,Maizels N,Steitz JA
Tue Mar 28 00:00:00 UTC 2000
HuR binding to cytoplasmic mRNA is perturbed by heat shock.
Proceedings of the National Academy of Sciences of the United States of America
Gallouzi IE,Brennan CM,Stenberg MG,Swanson MS,Eversole A,Maizels N,Steitz JA
Tue Mar 28 00:00:00 UTC 2000
