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Product Details
PA5-107148
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the C-terminal region of human INSM1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.4, with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2817864
Product Specific Information
Sequence homology: Cow: 86%; Dog: 92%; Horse: 85%; Human: 100%; Pig: 92%
Target Information
IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: insulinoma associated 1; insulinoma-associated 1; Insulinoma-associated protein 1; Zinc finger protein IA-1
Gene Aliases: IA-1; IA1; INSM1
UniProt ID: (Human) Q01101
Entrez Gene ID: (Human) 3642
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
cyclin binding
chromatin DNA binding
histone deacetylase binding
metal ion binding
negative regulation of transcription from RNA polymerase II promoter
negative regulation of protein phosphorylation
type B pancreatic cell differentiation
pancreatic A cell differentiation
type B pancreatic cell development
noradrenergic neuron development
transcription, DNA-templated
cell cycle
negative regulation of cell proliferation
regulation of gene expression
positive regulation of cell migration
endocrine pancreas development
norepinephrine biosynthetic process
regulation of protein complex assembly
positive regulation of cell differentiation
transdifferentiation
adrenal chromaffin cell differentiation
sympathetic ganglion development
positive regulation of cell cycle arrest
positive regulation of neural precursor cell proliferation
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