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This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
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Protein Aliases: 69 kDa islet cell autoantigen; diabetes mellitus type I autoantigen; ica1 {ECO:0000312|RGD:621465}; ICA69; ICAp69; Islet cell autoantigen 1; islet cell autoantigen 1 isoform; islet cell autoantigen 1, 69 kDa; islet cell autoantigen 1, 69kDa; Islet cell autoantigen p69; p69; testicular tissue protein Li 162
Gene Aliases: ICA1; ICA69; ICAp69
UniProt ID: (Human) Q05084
Entrez Gene ID: (Human) 3382, (Rat) 81024
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