Invitrogen

ICAM-1 (CD54) Polyclonal Antibody

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1 Reference
View all (171) ICAM-1 (CD54) antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-79430

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E.coli-derived mouse ICAM1 recombinant protein (Position: G198-P537).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2746546

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: rat NRK whole cell, mouse spleen tissue, mouse liver tissue, mouse kidney tissue, mouse ANA-1 whole cell. IHC: mouse liver tissue, mouse lung tissue, rat lung tissue, rat liver tissue.

Target Information

ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CD54; Human rhinovirus receptor; ICAM-1; Intercellular adhesion molecule 1; Ly 47; MALA-2; MALA2; MyD10; sCD54; soluble CD54; Surface antigen of activated B cells

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Gene Aliases: CD54; ICAM; Icam-1; Icam1; Ly-47; MALA-2

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UniProt ID: (Mouse) P13597, (Rat) Q00238

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Entrez Gene ID: (Mouse) 15894, (Rat) 25464

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Function(s)
integrin binding protein complex binding
Process(es)
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell acute inflammatory response to antigenic stimulus T cell antigen processing and presentation positive regulation of cellular extravasation cell adhesion leukocyte cell-cell adhesion sensory perception of sound regulation of cell shape single organismal cell-cell adhesion regulation of cell adhesion positive regulation of actin filament polymerization cell adhesion mediated by integrin positive regulation of GTPase activity adhesion of symbiont to host positive regulation of nitric oxide biosynthetic process positive regulation of vasoconstriction receptor-mediated virion attachment to host cell positive regulation of peptidyl-tyrosine phosphorylation positive regulation of NF-kappaB transcription factor activity negative regulation of calcium ion transport establishment of endothelial barrier positive regulation of ERK1 and ERK2 cascade cellular response to glucose stimulus establishment of Sertoli cell barrier regulation of ruffle assembly negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of endothelial cell apoptotic process ovarian follicle development response to hypoxia response to amphetamine cell aging response to ionizing radiation response to sulfur dioxide response to organic cyclic compound membrane to membrane docking cellular response to nutrient levels response to lipopolysaccharide response to gonadotropin response to drug response to amino acid response to ethanol response to copper ion leukocyte migration cellular response to lipopolysaccharide cellular response to organic substance cellular response to alkaloid cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to hypoxia
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