Invitrogen

ID1 Recombinant Rabbit Monoclonal Antibody (JM92-13)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-32749

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:50-1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JM92-13

Immunogen

Synthetic peptide within Human Id1 aa 11-60
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2810026

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

ID1 is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. It has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene.The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: bHLHb24; Class B basic helix-loop-helix protein 24; dJ857M17.1.2; dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein); DNA-binding protein inhibitor ID-1; Inhibitor of differentiation 1; Inhibitor of DNA binding 1; inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

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Gene Aliases: BHLHB24; ID; ID1

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UniProt ID: (Human) P41134

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Entrez Gene ID: (Human) 3397

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Function(s)
transcription factor activity, sequence-specific DNA binding protein binding protein C-terminus binding transcription factor binding protein homodimerization activity protein self-association protein N-terminus binding proteasome binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis endothelial cell morphogenesis transcription, DNA-templated transforming growth factor beta receptor signaling pathway brain development heart development circadian rhythm negative regulation of transcription by transcription factor localization positive regulation of gene expression neuron differentiation BMP signaling pathway protein destabilization positive regulation of actin filament bundle assembly collagen metabolic process cell-abiotic substrate adhesion negative regulation of apoptotic process regulation of MAPK cascade negative regulation of sequence-specific DNA binding transcription factor activity blood vessel endothelial cell migration negative regulation of endothelial cell differentiation negative regulation of osteoblast differentiation regulation of angiogenesis negative regulation of transcription, DNA-templated response to antibiotic blood vessel morphogenesis positive regulation of epithelial cell proliferation negative regulation of dendrite morphogenesis lung morphogenesis lung vasculature development cellular response to epidermal growth factor stimulus negative regulation of protein homodimerization activity cellular response to peptide negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding cellular response to dopamine cellular response to nerve growth factor stimulus
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