Proteintech

IDE Polyclonal Antibody

IDE Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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IDE Antibody (21728-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human kidney using 21728-1-AP (IDE antibody) at dilution of 1:50 (under 40x lens).

IDE Antibody in Immunoprecipitation (IP)

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Product Details

21728-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IDE Fusion Protein Ag16392 (676-1019 aa encoded by BC096336)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to IDE.

Immunogen sequence: EQPHQHAMY YLRLLMTEVA WTKDELKEAL DDVTLPRLKA FIPQLLSRLH IEALLHGNIT KQAALGIMQM VEDTLIEHAH TKPLLPSQLV RYREVQLPDR GWFVYQQRNE VHNNCGIEIY YQTDMQSTSE NMFLELFCQI ISEPCFNTLR TKEQLGYIVF SGPRRANGIQ GLRFIIQSEK PPHYLESRVE AFLITMEKSI EDMTEEAFQK HIQALAIRRL DKPKKLSAEC AKYWGEIISQ QYNFDRDNTE VAYLKTLTKE DIIKFYKEML AVDAPRRHKV SVHVLAREMD SCPVVGEFPC QNDINLSQAP ALPQPEVIQN MTEFKRGLPL FPLVKPHINF MAAKL (676-1019 aa encoded by BC096336)

Target Information

This gene may belong to a protease family responsible for intercellular peptide signalling. Though its role in the cellular processing of insulin has not yet been defined, insulin-degrading enzyme is thought to be involved in the termination of the insulin response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Ginsenoside ompound K reduces neuronal damage and improves neuronal synaptic dysfunction by targeting Aβ.

Frontiers in pharmacology

Li N,Pang Q,Zhang Y,Lin J,Li H,Li Z,Liu Y,Fang X,An Y,Bai H,Li D,Cao Z,Liu J,Yang Q,Hu S

Tue Mar 07 00:00:00 UTC 2023

Ginsenoside ompound K reduces neuronal damage and improves neuronal synaptic dysfunction by targeting Aβ.

Frontiers in pharmacology

Li N,Pang Q,Zhang Y,Lin J,Li H,Li Z,Liu Y,Fang X,An Y,Bai H,Li D,Cao Z,Liu J,Yang Q,Hu S

Tue Mar 07 00:00:00 UTC 2023

A novel pectin from Polygala tenuifolia blocks Aβ₄₂ aggregation and production by enhancing insulin-degradation enzyme and neprilysin.

International journal of biological macromolecules

Zeng H,Li P,Zhou L,Ding K

Thu Oct 15 00:00:00 UTC 2020

OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.

Biochimica et biophysica acta. Molecular basis of disease

Yuan C,Guo X,Zhou Q,Du F,Jiang W,Zhou X,Liu P,Chi T,Ji X,Gao J,Chen C,Lang H,Xu J,Liu D,Yang Y,Qiu S,Tang X,Chen G,Zou L

Tue Jan 01 00:00:00 UTC 2019

OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.

Biochimica et biophysica acta. Molecular basis of disease

Yuan C,Guo X,Zhou Q,Du F,Jiang W,Zhou X,Liu P,Chi T,Ji X,Gao J,Chen C,Lang H,Xu J,Liu D,Yang Y,Qiu S,Tang X,Chen G,Zou L

Tue Jan 01 00:00:00 UTC 2019

Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.

Journal of molecular neuroscience : MN

Yang Q,Lin J,Zhang H,Liu Y,Kan M,Xiu Z,Chen X,Lan X,Li X,Shi X,Li N,Qu X

Tue Jan 01 00:00:00 UTC 2019

Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.

Journal of molecular neuroscience : MN

Yang Q,Lin J,Zhang H,Liu Y,Kan M,Xiu Z,Chen X,Lan X,Li X,Shi X,Li N,Qu X

Tue Jan 01 00:00:00 UTC 2019

MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.

Brain : a journal of neurology

Zhu BL,Long Y,Luo W,Yan Z,Lai YJ,Zhao LG,Zhou WH,Wang YJ,Shen LL,Liu L,Deng XJ,Wang XF,Sun F,Chen GJ

Tue Jan 01 00:00:00 UTC 2019

Ginsenoside compound K ameliorates Alzheimer's disease in HT22 cells by adjusting energy metabolism.

Molecular biology reports

Chen X,Li H,Yang Q,Lan X,Wang J,Cao Z,Shi X,Li J,Kan M,Qu X,Li N

Tue Oct 01 00:00:00 UTC 2019

A pectin from fruits of Lycium barbarum L. decreases β-amyloid peptide production through modulating APP processing.

Carbohydrate polymers

Zhou L,Liao W,Zeng H,Yao Y,Chen X,Ding K

Sat Dec 01 00:00:00 UTC 2018

A pectin from fruits of Lycium barbarum L. decreases β-amyloid peptide production through modulating APP processing.

Carbohydrate polymers

Zhou L,Liao W,Zeng H,Yao Y,Chen X,Ding K

Sat Dec 01 00:00:00 UTC 2018

Novel Serum Biomarkers Detected by Protein Array in Polycystic Ovary Syndrome with Low Progesterone Level.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Zheng Q,Zhou F,Cui X,Liu M,Li Y,Liu S,Tan J,Yan Q

Fri Aug 17 00:00:00 UTC 2018

Novel Serum Biomarkers Detected by Protein Array in Polycystic Ovary Syndrome with Low Progesterone Level.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Zheng Q,Zhou F,Cui X,Liu M,Li Y,Liu S,Tan J,Yan Q

Fri Aug 17 00:00:00 UTC 2018

Activation of α7 nicotinic acetylcholine receptor alleviates Aβ_1-42-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways.

Neurochemistry international

Chang KW,Zong HF,Ma KG,Zhai WY,Yang WN,Hu XD,Xu JH,Chen XL,Ji SF,Qian YH

Thu Nov 01 00:00:00 UTC 2018

Effect of naringenin on brain insulin signaling and cognitive functions in ICV-STZ induced dementia model of rats.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Yang W,Ma J,Liu Z,Lu Y,Hu B,Yu H

Thu May 01 00:00:00 UTC 2014

Effect of naringenin on brain insulin signaling and cognitive functions in ICV-STZ induced dementia model of rats.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Yang W,Ma J,Liu Z,Lu Y,Hu B,Yu H

Thu May 01 00:00:00 UTC 2014

Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a.

The Journal of biological chemistry

Kakiya N,Saito T,Nilsson P,Matsuba Y,Tsubuki S,Takei N,Nawa H,Saido TC

Fri Aug 24 00:00:00 UTC 2012

The Journal of biological chemistry

Kakiya N,Saito T,Nilsson P,Matsuba Y,Tsubuki S,Takei N,Nawa H,Saido TC

Fri Aug 24 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: Abeta-degrading protease; FLJ35968; Insulin degrading enzyme; Insulin protease; Insulin-degrading enzyme; Insulinase; Insulysin

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Gene Aliases: IDE; INSULYSIN

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UniProt ID: (Human) P14735

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Entrez Gene ID: (Human) 3416

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Function(s)

beta-amyloid binding virus receptor activity glycoprotein binding metalloendopeptidase activity receptor binding protein binding ATP binding zinc ion binding ATPase activity beta-endorphin binding peptide binding protein homodimerization activity ubiquitin binding insulin binding

Process(es)

proteolysis insulin receptor signaling pathway determination of adult lifespan bradykinin catabolic process ubiquitin homeostasis protein processing positive regulation of protein oligomerization hormone catabolic process negative regulation of proteolysis viral entry into host cell beta-amyloid metabolic process protein homooligomerization protein homotetramerization protein heterooligomerization proteolysis involved in cellular protein catabolic process insulin metabolic process insulin catabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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IDE Polyclonal Antibody

IDE Antibody (21728-1-AP) in IHC (P)

Product Details

21728-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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