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Invitrogen
IDE Recombinant Rabbit Monoclonal Antibody (JJ0949)
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Product Details
MA5-32494
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JJ0949
Immunogen
Recombinant protein within Human Insulin degrading enzyme aa 1-106
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2809771
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
This gene may belong to a protease family responsible for intercellular peptide signalling. Though its role in the cellular processing of insulin has not yet been defined, insulin-degrading enzyme is thought to be involved in the termination of the insulin response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Abeta-degrading protease; FLJ35968; Insulin degrading enzyme; Insulin protease; Insulin-degrading enzyme; Insulinase; Insulysin
Gene Aliases: 1300012G03Rik; 4833415K22Rik; AA675336; AI507533; IDE; INSDEGM; INSULYSIN; zgc:162603
UniProt ID: (Human) P14735, (Rat) P35559
Entrez Gene ID: (Human) 3416, (Rat) 25700, (Mouse) 15925, (Zebrafish) 561390
beta-amyloid binding
virus receptor activity
glycoprotein binding
metalloendopeptidase activity
receptor binding
protein binding
ATP binding
zinc ion binding
ATPase activity
beta-endorphin binding
peptide binding
protein homodimerization activity
ubiquitin binding
insulin binding
peptidase activity
peptide hormone binding
nucleotide binding
catalytic activity
metallopeptidase activity
hydrolase activity
metal ion binding
proteolysis
insulin receptor signaling pathway
determination of adult lifespan
bradykinin catabolic process
ubiquitin homeostasis
protein processing
positive regulation of protein oligomerization
hormone catabolic process
negative regulation of proteolysis
viral entry into host cell
beta-amyloid metabolic process
protein homooligomerization
protein homotetramerization
protein heterooligomerization
proteolysis involved in cellular protein catabolic process
insulin metabolic process
insulin catabolic process
peptide catabolic process
cellular protein catabolic process
metabolic process
type B pancreatic cell development
endocrine pancreas development
pancreas regeneration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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