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Invitrogen
IEX-1 Polyclonal Antibody
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Product Details
PA5-20391
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 24 amino acid peptide near the center of human IEX1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11156222
Product Specific Information
A suggested positive control is human brain tissue lysate.
PA5-20391 can be used with blocking peptide PEP-0508.
Target Information
IEX-1 is a stress inducible gene that is induced by ionizing radiation, ultraviolet radiation, and a variety of growth factors, i.e., FAS and TNF-a. IEX-1 is widely expressed in epithelial and endocrine tissues, as well as in vascular endothelium. It plays an important role in the regulation of cellular growth, cell death and oncogenesis. IEX-1 is precisely regulated by multiple transcription factors such as p53, NF-kappa-B/rel, Sp1 and c-Myc, to ensure rapid and transient expression of IEX-1 in cells under a variety of stress conditions. IEX-1 is expressed as both a longer form (IEX1L) and a splice variant, designated IEX1S. It is localized to the nucleus and perinuclear region. Overexpression of IEX-1 facilitates apoptosis and cell cycle progression, whereas disruption of IEX-1 expression is associated with decreases in both apoptosis and cell cycle progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: anti-death protein; cAMP inducible gene 3; DADB-118P11.5; Differentiation-dependent gene 2 protein; expressed in pancreatic carcinoma; gly96, mouse, homolog of; Immediate early protein GLY96; Immediate early response 3 protein; immediately early gene X-1; PACAP-responsive gene 1 protein; Protein DIF-2; Protein PRG1; Radiation-inducible immediate-early gene IEX-1
Gene Aliases: AI663993; cI-3; DIF-2; DIF2; GLY96; IER3; IEX-1; IEX-1L; IEX1; PRG1
UniProt ID: (Human) P46695, (Mouse) P46694
Entrez Gene ID: (Human) 8870, (Mouse) 15937
apoptotic process
anatomical structure morphogenesis
regulation of phosphatidylinositol 3-kinase signaling
negative regulation of apoptotic process
regulation of response to DNA damage stimulus
response to protozoan
negative regulation of systemic arterial blood pressure
regulation of DNA repair
mitotic G2 DNA damage checkpoint
intrinsic apoptotic signaling pathway in response to DNA damage
positive regulation of protein catabolic process
negative regulation of glycolytic process
regulation of nucleocytoplasmic transport
negative regulation of inflammatory response
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
regulation of reactive oxygen species metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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