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Proteintech
IFIT5 Polyclonal Antibody
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Product Details
13378-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IFIT5 Fusion Protein Ag4202 (133-482 aa encoded by BC025786)
Conjugate
Form
Liquid
Concentration
0.57 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: YKLECPETD CEKGWALLKF GGKYYQKAKA AFEKALEVEP DNPEFNIGYA ITVYRLDDSD REGSVKSFSL GPLRKAVTLN PDNSYIKVFL ALKLQDVHAE AEGEKYIEEI LDQISSQPYV LRYAAKFYRR KNSWNKALEL LKKALEVTPT SSFLHHQMGL CYRAQMIQIK KATHNRPKGK DKLKVDELIS SAIFHFKAAM ERDSMFAFAY TDLANMYAEG GQYSNAEDIF RKALRLENIT DDHKHQIHYH YGRFQEFHRK SENTAIHHYL EALKVKDRSP LRTKLTSALK KLSTKRLCHN ALDVQSLSAL GFVYKLEGEK RQAAEYYEKA QKIDPENAEF LTALCELRLS I (133-482 aa encoded by BC025786)
Target Information
Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268). Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420). Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268). Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7 (PubMed:26334375). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: IFIT-5; Interferon-induced 58 kDa protein; Interferon-induced protein with tetratricopeptide repeats 5; P58; Retinoic acid- and interferon-inducible 58 kDa protein; retinoic acid- and interferon-inducible protein (58kD)
Gene Aliases: IFIT5; ISG58; P58; RI58
UniProt ID: (Human) Q13325
Entrez Gene ID: (Human) 24138
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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