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Invitrogen
IFNAR1 Recombinant Rabbit Monoclonal Antibody (SR45-08)
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FIGURE: 1 / 7
IFNAR1 Antibody (MA5-32006) in ICC/IF
Immunocytochemistry analysis of IFNAR1 with Jurkat cells. Cells were fixed in 4% paraformaldehyde (20 min, room temp), permeabilized with 0.1% Triton X-100 in PBS (5 min, room temp), then blocked with 1% BSA in 10% negative goat serum (1 hr, room temp), incubated with recombinant monoclonal IFNAR1 (Product # MA5-32006) at a dilution of 1:100 (in 1% BSA in PBST overnight at 4°C), followed by Goat Anti-Rabbit IgG H&L 488 at 1:1,000 dilution (PBS used in control). Nuclear DNA was labelled in blue with DAPI, Beta tubulin (red) at 1/100 dilutio... View More
Product Details
MA5-32006
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SR45-08
Immunogen
Synthetic peptide within Human IFNAR1 aa 508-557
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2809300
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron,2001, Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-& Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha-type antiviral protein; beta-type antiviral protein; CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; H3K1; IFN R1; IFN-alpha/beta receptor 1; IFN-alpha/betaR; IFN-alpha/betaR1; IFN-alpha/betaRalpha; IFN-R-1; IFNalpha/beta R1; IFNalpha/beta-Ralpha; IFNalpha/betaR1; IFNR1; INF-a receptor; interferon (alpha and beta) receptor 1; interferon (alpha, beta and omega) receptor 1; Interferon alpha/beta receptor 1; interferon receptor 1; interferon-alpha/beta receptor 1; interferon-alpha/beta receptor alpha chain; interferon-beta receptor 1; Type I interferon receptor 1
Gene Aliases: AVP; CD118; Ifar; IFN-alpha-REC; IFNAR; IFNAR1; IFNBR; IFRC; Infar
UniProt ID: (Human) P17181, (Mouse) P33896
Entrez Gene ID: (Human) 3454, (Rat) 288264, (Mouse) 15975
biological_process
cytokine-mediated signaling pathway
positive regulation of interferon-gamma production
T cell activation
type I interferon biosynthetic process
positive regulation of interleukin-1 beta secretion
regulation of peptidyl-tyrosine phosphorylation
defense response to virus
JAK-STAT cascade
response to virus
response to lipopolysaccharide
positive regulation of interferon-beta production
cellular response to interferon-alpha
positive regulation of transcription, DNA-templated
type I interferon signaling pathway
regulation of type I interferon-mediated signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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