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IFNGR2 Antibody (PA5-47089) in Neu
Neutralization of IFNGR2 in L‚929 mouse fibroblast cell line. Samples were incubated in IFNGR2 polyclonal antibody (Product # PA5-47089). Recombinant Mouse IFN‚γ reduces the Encephalomyocarditis Virus (EMCV)-induced cytopathy in the L‚929 mouse fibroblast cell line in a dose-dependent manner (orange line). Inhibition of EMCV activity elicited by Recombinant Mouse IFN‚γ (1 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti‚Mouse IFN‚γ R2 Antigen Affinity-purified Polyclonal Antibody. The ND50 is typically 0.2-0.8 µ... View More
Product Details
PA5-47089
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse IFN- gamma R2 Ser21-Val243
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2576218
Product Specific Information
In Western blots, approximately 5% cross-reactivity with recombinant human IFN-gamma R2 is observed and less than 1% cross-reactivity with recombinant mouse (rm) IFN- gamma R1 and rmIFN-alpha / beta R2 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: interferon gamma receptor 2
Gene Aliases: Ifgr2; Ifgt
Entrez Gene ID: (Mouse) 15980
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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