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Product Details
19304-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IFT122 Fusion Protein Ag6860 (1-359 aa encoded by BC004238)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MRAVLTWRD KAEHCINDIA FKPDGTQLIL AAGSRLLVYD TSDGTLLQPL KGHKDTVYCV AYAKDGLWSP EQKSVSKHKS SSKIICCSWT NDGQYLALGM FNGIISIRNK NGEEKVKIER PGGSLSPIWS ICWNPSREER NDILAVADWG QKVSFYQLSG KQIGKDRALN FDPCCISYFT KGEYILLGGS DKQVSLFTKD GVRLGTVGEQ NSWVWTCQAK PDSNYVVVGC QDGTISFYQL IFSTVHGLYK DRYAYRDSMT DVIVQHLITE QKVRIKCKEL VKKIAIYRNR LAIQLPEKIL IYELYSEDLS DMHYRVKEKI IKKFECNLLV VCANHIILCQ EKRLQCLSFS GVKEREWQME (1-359 aa encoded by BC004238)
Target Information
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: intraflagellar transport 122 homolog; Intraflagellar transport protein 122 homolog; WD repeat domain 10; WD repeat-containing protein 10; WD repeat-containing protein 140
Gene Aliases: C86139; CED; CED1; IFT122; sopb; SPG; WDR10; WDR10p; WDR140
UniProt ID: (Human) Q9HBG6, (Mouse) Q6NWV3
Entrez Gene ID: (Human) 55764, (Mouse) 81896
neural tube closure
signal transduction downstream of smoothened
multicellular organism development
dorsal/ventral pattern formation
embryonic body morphogenesis
negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
cell projection organization
embryonic heart tube development
embryonic forelimb morphogenesis
intraciliary anterograde transport
intraciliary retrograde transport
cilium assembly
embryonic digit morphogenesis
negative regulation of smoothened signaling pathway
camera-type eye morphogenesis
negative regulation of epithelial cell proliferation
limb development
cilium morphogenesis
ciliary receptor clustering involved in smoothened signaling pathway
smoothened signaling pathway involved in dorsal/ventral neural tube patterning
embryonic heart tube left/right pattern formation
protein localization to cilium
establishment of protein localization to organelle
intraciliary transport involved in cilium morphogenesis
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