Invitrogen

IGF2 Recombinant Rabbit Monoclonal Antibody (JJ092-3)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-32485

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JJ092-3

Immunogen

Recombinant protein within Human IGF2 aa 25-121
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809762

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ22066; FLJ44734; H-IGF-2; IGF; IGF-II; Insulin like growth factor; Insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A); Insulin-like growth factor II; insulin-like growth factor type 2; preptin; Somatomedin-A; T3M-11-derived growth factor

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Gene Aliases: C11orf43; GRDF; IGF-2; IGF-II; IGF2; PP1446; PP9974

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UniProt ID: (Human) P01344

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Entrez Gene ID: (Human) 3481

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Function(s)
insulin receptor binding insulin-like growth factor receptor binding hormone activity protein binding growth factor activity receptor activator activity protein serine/threonine kinase activator activity
Process(es)
skeletal system development ossification positive regulation of protein phosphorylation platelet degranulation glucose metabolic process regulation of gene expression by genetic imprinting regulation of transcription, DNA-templated multicellular organism development female pregnancy memory positive regulation of cell proliferation insulin receptor signaling pathway response to radiation response to nutrient levels response to estradiol response to nicotine insulin receptor signaling pathway via phosphatidylinositol 3-kinase wound healing positive regulation of activated T cell proliferation response to drug positive regulation of catalytic activity positive regulation of MAPK cascade cellular protein metabolic process response to ethanol positive regulation of glycogen biosynthetic process positive regulation of mitotic nuclear division negative regulation of natural killer cell mediated cytotoxicity positive regulation of insulin receptor signaling pathway positive regulation of peptidyl-tyrosine phosphorylation positive regulation of cell division positive regulation of protein kinase B signaling cellular response to mechanical stimulus positive regulation of protein serine/threonine kinase activity positive regulation of receptor activity positive regulation of glycogen (starch) synthase activity
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