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Invitrogen
IGF2BP2 Polyclonal Antibody
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Product Details
PA5-95923
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 330-599 of human IGF2BP2/IMP2 (NP_0065393)
Conjugate
Form
Liquid
Concentration
0.41 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2807725
Product Specific Information
Immunogen sequence: TVEACASAEI EIMKKLREAF ENDMLAVNQQ ANLIPGLNLS ALGIFSTGLS VLSPPAGPRG APPAAPYHPF TTHSGYFSSL YPHHQFGPFP HHHSYPEQEI VNLFIPTQAV GAIIGKKGAH IKQLARFAGA SIKIAPAEGP DVSERMVIIT GPPEAQFKAQ GRIFGKLKEE NFFNPKEEVK LEAHIRVPSS TAGRVIGKGG KTVNELQNLT SAEVIVPRDQ TPDENEEVIV RIIGHFFASQ TAQRKIREIV QQVKQQEQKY PQGVASQRSK; Positive Samples: HT-29, BxPC-3, HeLa, Jurkat, NIH3T3; Cellular Location: Cytoplasm, Nucleus
Target Information
IGF2BP2 is a member of the IGF-II mRNA-binding protein (IMP) family. It recruits target transcripts to cytoplasmic protein-RNA complexes. The protein contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; IGF2 mRNA-binding protein 2; insulin-like growth factor 2 mRNA binding protein 2; Insulin-like growth factor 2 mRNA-binding protein 2; insulin-like growth factor 2, binding protein 2; p62; VICKZ family member 2
Gene Aliases: C330012H03Rik; IGF2BP2; IMP-2; IMP2; Neilsen; RGD1305614; VICKZ2
UniProt ID: (Human) Q9Y6M1, (Mouse) Q5SF07
Entrez Gene ID: (Human) 10644, (Mouse) 319765, (Rat) 303824
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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