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Invitrogen
IGFBP2 Polyclonal Antibody
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FIGURE: 1 / 9
IGFBP2 Antibody (PA5-79450) in ICC/IF
Immunocytochemistry analysis of IGFBP2 using anti-IGFBP2 antibody (Product # PA5-79450). IGFBP2 was detected in a section of NRK cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum and then incubated with 2μg/mL rabbit anti-IGFBP2 antibody (Product # PA5-79450)overnight at 4°C. DyLight®550 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody at 1:100 dilution and incubated for 30 minutes at 37°C. The section was counterstained with DAPI. ... View More
Product Details
PA5-79450
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived rat IGFBP2 recombinant protein (Position: E35-Q304).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2746566
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat liver tissue, mouse Neuro-2a whole cell, mouse HEPA1-6 whole cell. IHC: mouse small intestine tissue, mouse brain tissue, mouse kidney tissue, rat brain tissue, rat lung tissue. ICC/IF: NRK cell. Flow: RH35 cell.
Target Information
IGFBP2 (insulin-like growth factor binding protein 2) is a member of the ISGBP family which bind various IGFs. IGFBP2 is overexpressed in a wide spectrum of cancers, including glioma, prostate cancer, synovial sarcoma, neuroblastoma, colon cancer, adrenocortical cancer, lung cancer, Wilms' tumor, and hepatoblastoma. The overexpression of IGFBP2 also correlates with the aggressiveness of some tumors. IGFBP2 activates the expression of matrix metalloprotease 2, which contributes to cell invasiveness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BRL-BP; IBP-2; IGF binding protein 2; IGF-binding protein 2; IGFBP; Insulin like growth factor binding protein; insulin-like growth factor binding protein 2; insulin-like growth factor binding protein 2, 36kDa; Insulin-like growth factor-binding protein 2; OTTHUMP00000207753
Gene Aliases: AI255832; BP2; IBP-2; IBP2; IGF-BP53; IGFBP-2; IGFBP2; ILGFBPA; mIGFBP-2
UniProt ID: (Human) P18065, (Mouse) P47877, (Rat) P12843
Entrez Gene ID: (Human) 3485, (Mouse) 16008, (Rat) 25662
regulation of cell growth
regulation of growth
positive regulation of activated T cell proliferation
regulation of insulin-like growth factor receptor signaling pathway
signal transduction
multicellular organism development
female pregnancy
aging
response to nutrient
response to mechanical stimulus
response to lithium ion
response to estradiol
response to retinoic acid
cellular response to hormone stimulus
response to drug
response to estrogen
response to steroid hormone
response to glucocorticoid
cellular protein metabolic process
negative regulation of canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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