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Bioss
IGFBP5 Polyclonal Antibody
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Product Details
BS-0406R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human IGFBP5, amino acids 101-200.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The insulin-like growth factor-binding proteins, or IGFBPs, are a family of homologous proteins that have co-evolved with the IGFs. They serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, as well as their concentration and distribution in the extracellular environment. In addition, the IGFBPs appear to have biological activity independent of the IGFs. Seven IGFBPs have thus far been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. For instance, IGFBP1 is negatively regulated by insulin production. The IGFBP1 gene is expressed at a high level during fetal liver development and in response to nutritional changes and diabetes. It has been suggested that IGFBP2 functions as chaperone, escorting IGFs to their target tissues. It is expressed in several human tissues including fetal eye and fetal brain. IGFBP3 is the most abundant IGFBP and is complexed with roughly 80% of the serum IGFs. Both IGFBP3 and IGFBP4 are released by dermal fibroblasts in response to incision injury. IGFBP5 is secreted by myoblasts and may play a key role in muscle differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IBP 5; IBP-5; IGF BP5; IGF-binding protein 5; IGFBP; IGFBP 5; IGFBP-5; Insulin like growth factor binding protein; insulin-like growth factor binding protein 5; Insulin-like growth factor-binding protein 5
Gene Aliases: AI256729; AW208790; IBP5; IGF-BP5; IGFBP-5; IGFBP-5P; IGFBP5
UniProt ID: (Human) P24593, (Mouse) Q07079, (Rat) P24594
Entrez Gene ID: (Human) 3488, (Mouse) 16011, (Rat) 25285
regulation of cell growth
glucose metabolic process
regulation of glucose metabolic process
negative regulation of smooth muscle cell migration
negative regulation of translation
negative regulation of cell migration
hair follicle morphogenesis
regulation of growth
glucose homeostasis
positive regulation of insulin-like growth factor receptor signaling pathway
negative regulation of insulin-like growth factor receptor signaling pathway
type B pancreatic cell proliferation
negative regulation of osteoblast differentiation
negative regulation of smooth muscle cell proliferation
striated muscle cell differentiation
positive regulation of protein kinase B signaling
mammary gland involution
cellular response to cAMP
cellular response to organic cyclic compound
osteoblast differentiation
intracellular signal transduction
regulation of insulin-like growth factor receptor signaling pathway
skeletal muscle tissue growth
response to growth hormone
signal transduction
female pregnancy
cellular protein metabolic process
negative regulation of growth
lung alveolus development
negative regulation of muscle tissue development
negative regulation of skeletal muscle hypertrophy
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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