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Product Details
26047-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IGSF2 Fusion Protein Ag23297 (260-603 aa encoded by BC136484)
Conjugate
Form
Liquid
Concentration
0.32 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody specifically recognizes the 115 kDa protein.
Immunogen sequence: ETWMFITKK QTDQTTLRIQ PAVKDFQVNI TADSLFAEGK PLELVCLVVS SGRDPQLQGI WFFNGTEIAH IDAGGVLGLK NDYKERASQG ELQVSKLGPK AFSLKIFSLG PEDEGAYRCV VAEVMKTRTG SWQVLQRKQS PDSHVHLRKP AARSVVVSTK NKQQVVWEGE TLAFLCKAGG AESPLSVSWW HIPRDQTQPE FVAGMGQDGI VQLGASYGVP SYHGNTRLEK MDWATFQLEI TFTAITDSGT YECRVSEKSR NQARDLSWTQ KISVTVKSLE SSLQVSLMSR QPQVMLTNTF DLSCVVRAGY SDLKVPLTVT WQFQPASSHI FHQLIRITHN GTIEW (260-603 aa encoded by BC136484)
Target Information
CD101 also known as V7 antigen, a member of the Ig superfamily. CD101 is a disulfide linked homodimer of unknown function. Expression of CD101 is found on monocytes, granulocytes and dendritic cells (Langerhan-like cells HLA-DR, CD1a, CD1c). In addition expression on T lymphocytes is important for cell activation. CD101+ CD28+ cells are very responsive to CD28 signaling. In combination with anti-CD28 or suboptimal levels of anti-CD3, anti-CD101 can increase proliferation thereby suggesting an activating role. The monoclonal antibody BB27 has been shown to inhibit the T cell reactivity in allogeneic and antigen-specific mixed DC-T cell cultures. Recently it has been demonstrated that mouse CD101 is found on a subpopulation of regulatory T cells (CD4, CD25, Foxp3 positive) that have high suppressor activity. Expression of CD101 on human PBMCs shows staining of about 30% of the Foxp3 positive cells. Studies have not confirmed higher suppressor activity in the human CD101 population.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD101; Cell surface glycoprotein V7; EWI immunoglobulin subfamily member EWI-101; EWI-101; Glu-Trp-Ile EWI motif-containing protein 101; IgSF2; Immunoglobulin superfamily member 2; immunoglobulin superfamily, member 2; leukocyte surface protein; RP11-27K13.2
Gene Aliases: CD101; EWI-101; EWI101; Gm1016; Gm734; IGSF2; V7
UniProt ID: (Human) Q93033, (Mouse) A8E0Y8
Entrez Gene ID: (Human) 9398, (Mouse) 630146
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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