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Invitrogen
IKAP Polyclonal Antibody
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Product Details
PA1-4163
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues I(148) H Q D D F G E S K F I T V(161) of huamn IKAP.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2122035
Product Specific Information
PA1-4163 detects IKAP in human samples.
PA1-4163 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~158 kDa protein representing IKAP in Interleukin-1-stimulated 293 cells.
The PA1-4163 immunogen is a synthetic peptide corresponding to residues I(148) H Q D D F G E S K F I T V(161) of huamn IKAP. This sequence is 92% conserved in rat, and 85% conserved in mouse.
Target Information
The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781H1425; elongator acetyltransferase complex subunit 1; Elongator complex protein 1; ELP1; FLJ12497; IkappaB kinase complex-associated protein; IKK complex-associated protein; p150; RP11-3J11.4
Gene Aliases: DYS; ELP1; FD; IKAP; IKBKAP; IKI3; TOT1
UniProt ID: (Human) O95163
Entrez Gene ID: (Human) 8518
tRNA wobble uridine modification
regulation of transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
protein complex assembly
protein phosphorylation
immune response
signal transduction
positive regulation of cell migration
regulation of protein kinase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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