Rockland

IKK alpha Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

100-401-219

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:500
-

ELISA (ELISA)

1:5,000-1:25,000
-

Immunoprecipitation (IP)

1:500-1:3,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IKK a peptide corresponding to the highly conserved C-terminus region of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

80 mg/mL

Storage buffer

whole serum

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Anti- IKK a may react non-specifically with other proteins. Control peptide (code #100-401-219p) will compete only with the specific reaction of antiserum with the IKK a subunit.

Target Information

CHUK (IKK alpha) is a serine/threonine kinase involved in signal transduction and cellular communication. It belongs to the cytokine activated protein complex that is an inhibitor of the NF-kappa B complex. IKK alpha along with IKK beta and a regulatory protein NEMO (IKK gamma) phosphorylates IkB proteins which targets the later for ubiquitin mediated degradation. It is involved with several cellular processes with extensive studies on its role in inflammation and cell survival.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Conserved helix-loop-helix ubiquitous kinase; EC 2.7.11.10; FLJ40509; I kappa B kinase 1; I-kappa-B kinase 1; I-kappa-B kinase 2; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; ikappaB kinase; IkappaB kinase alpha; IkB kinase alpha subunit; IKBKB; IKK alpha; IKK-1; IKK-A; IKK-a kinase; IKK-B; IKK-beta; IKK2; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit alpha; kinase beta; MGC131801; NFKBIKA; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; TCF-16; Transcription factor 16

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Gene Aliases: AI256658; CHUK; Chuk1; Fbx24; Fbxo24; IKBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16

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UniProt ID: (Human) O15111

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Entrez Gene ID: (Human) 1147, (Mouse) 12675, (Rat) 309361

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Function(s)
protein kinase activity protein binding ATP binding IkappaB kinase activity protein homodimerization activity protein heterodimerization activity scaffold protein binding nucleotide binding protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
morphogenesis of an epithelial sheet protein phosphorylation I-kappaB phosphorylation Rho protein signal transduction lactation response to organic substance phosphorylation signal transduction by protein phosphorylation osteoclast differentiation response to lipopolysaccharide mammary gland epithelial cell proliferation response to muscle stretch odontogenesis of dentin-containing tooth positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of transcription from RNA polymerase II promoter striated muscle cell differentiation mammary gland alveolus development cellular response to tumor necrosis factor stimulatory C-type lectin receptor signaling pathway skeletal muscle contraction inflammatory response immune response I-kappaB kinase/NF-kappaB signaling response to virus response to toxic substance anatomical structure morphogenesis response to acetate regulation of tumor necrosis factor-mediated signaling pathway response to hydroperoxide TRIF-dependent toll-like receptor signaling pathway NIK/NF-kappaB signaling Fc-epsilon receptor signaling pathway response to drug response to amino acid innate immune response T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity stress-activated MAPK cascade nucleotide-binding oligomerization domain containing signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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