Invitrogen

IL-1 alpha Polyclonal Antibody

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Questions & Answers

Product Details

PA5-96081

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 112-271 of human IL-1 alpha (NP_0005663)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.42 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2807883

Product Specific Information

Positive Samples: NCI-H460, SKOV3, HeLa

Immunogen sequence: RSAPFSFLSN VKYNFMRIIK YEFILNDALN QSIIRANDQY LTAAALHNLD EAVKFDMGAY KSSKDDAKIT VILRISKTQL YVTAQDEDQP VLLKEMPEIP KTITGSETNL LFFWETHGTK NYFTSVAHPN LFIATKQDYW VCLAGGPPSI TDFQILENQA

Target Information

IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 alpha is coded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 beta. IL1A is located on the q arm on chromosome 2 at position 13. IL-1 alpha plays an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. IL-1 alpha activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. Further, IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury and induces apoptosis. The IL1A gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL1 alpha regulates the activities of NF-kappaB and mitogen-activated protein kinases. IL-1 alpha can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-1 alpha are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CTLA8; Hematopoietin-1; IL 1 a; IL 1α; IL-1 alpha; IL17; IL1α; ILN; Interleukin; interleukin 1, alpha; interleukin 17; Interleukin-1 alpha; Interleukin-17A; Interleukin1 alpha; preinterleukin 1 alpha; pro-interleukin-1-alpha; RP23-160G19.8

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Gene Aliases: IL-1 alpha; IL-1A; IL1; IL1-ALPHA; IL1A; IL1F1

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UniProt ID: (Human) P01583, (Mouse) P01582, (Rat) P16598

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Entrez Gene ID: (Human) 3552, (Mouse) 16175, (Rat) 24493

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Function(s)
cytokine activity interleukin-1 receptor binding copper ion binding protein binding
Process(es)
fever generation connective tissue replacement involved in inflammatory response wound healing apoptotic process inflammatory response immune response cell proliferation negative regulation of cell proliferation positive regulation of vascular endothelial growth factor production positive regulation of gene expression cytokine-mediated signaling pathway cellular response to heat ectopic germ cell programmed cell death positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of interleukin-2 biosynthetic process positive regulation of angiogenesis positive regulation of mitotic nuclear division positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade response to copper ion positive regulation of protein secretion positive regulation of cytokine secretion positive regulation of cell division extrinsic apoptotic signaling pathway in absence of ligand negative regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of steroid biosynthetic process keratinization positive regulation of prostaglandin secretion positive regulation of interleukin-6 production positive regulation of stress-activated MAPK cascade regulation of sensory perception of pain positive regulation of ERK1 and ERK2 cascade positive regulation of neutrophil migration response to hypoxia acute inflammatory response spermatogenesis heart development response to heat response to organic substance response to ozone response to organonitrogen compound response to gamma radiation response to organic cyclic compound response to lipopolysaccharide response to L-ascorbic acid wound healing
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