Invitrogen

IL-1 beta Polyclonal Antibody, Biotin

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PBOIL1BBI

Applications
Tested Dilution
Publications

ELISA (ELISA)

Assay-dependent
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Product Specifications

Species Reactivity

Bovine

Published species

Bovine

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Bovine IL-1 beta

Conjugate

Biotin Biotin Biotin

Form

Lyophilized

Concentration

0.25 mg/mL

Purification

Protein G

Storage buffer

Dulbecco's PBS

Contains

proprietary preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_417099

Product Specific Information

PBOIL1BBI targets IL-1 beta in ELISA applications and shows reactivity with Bovine samples.



The PBOIL1BBI immunogen is recombinant Bovine IL-1 beta.



PBOIL1BBI detects IL-1 beta which has a predicted molecular weight of approximately 18 kDa.

Target Information

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Hematopoietin 1 (H1); IFN beta inducing factor; il 1b; IL 1β; IL-1 beta; IL1 B; IL1β; ILN; Interleukin; Interleukin 1 beta precursor; Interleukin-1 beta; Interleukin-1b; Interleukin1 beta; LAF; Osteoclast activating factor (OAF); Pro interleukin 1 beta

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Gene Aliases: BOS_11619; IL1B

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UniProt ID: (Bovine) P09428

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Entrez Gene ID: (Bovine) 281251

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Function(s)
cytokine activity interleukin-1 receptor binding growth factor activity protein domain specific binding
Process(es)
MAPK cascade activation of MAPK activity fever generation immune response negative regulation of cell proliferation positive regulation of vascular endothelial growth factor production negative regulation of glucose transport cytokine-mediated signaling pathway hyaluronan biosynthetic process neutrophil chemotaxis sequestering of triglyceride positive regulation of fever generation lipopolysaccharide-mediated signaling pathway positive regulation of prostaglandin secretion interleukin-1 beta production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-6 production positive regulation of interleukin-8 production response to ATP positive regulation of heterotypic cell-cell adhesion positive regulation of myosin light chain kinase activity cellular response to drug positive regulation of T cell proliferation positive regulation of NF-kappaB import into nucleus negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAP kinase activity protein kinase B signaling positive regulation of chemokine biosynthetic process positive regulation of interleukin-2 biosynthetic process positive regulation of interleukin-6 biosynthetic process positive regulation of nitric oxide biosynthetic process positive regulation of angiogenesis positive regulation of mitotic nuclear division positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade negative regulation of insulin receptor signaling pathway regulation of insulin secretion negative regulation of lipid catabolic process positive regulation of lipid catabolic process positive regulation of membrane protein ectodomain proteolysis positive regulation of NF-kappaB transcription factor activity positive regulation of cell division positive regulation of calcidiol 1-monooxygenase activity negative regulation of adiponectin secretion monocyte aggregation cellular response to mechanical stimulus cellular response to organic cyclic compound positive regulation of monocyte chemotactic protein-1 production
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