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Invitrogen
IL-12/IL-23 p40 Polyclonal Antibody
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IL-12/IL-23 p40 Antibody (PA5-46917) in Neu
Neutralization of IL-12/IL-23 p40 in PHA-activated human peripheral blood mononuclear cells (PBMC). Samples were incubated in IL-12/IL-23 p40 polyclonal antibody (Product # PA5-46917) using a dilution of 25 ng/mL. Recombinant Canine IL‚12 stimulates proliferation in PHA-activated human peripheral blood mononuclear cells (PBMC) in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Canine IL‚12 is neutralized (green line) by increasing concentrations of Goat Anti-Canine IL‚12/IL‚23 p40 Antigen Affinity-purified Poly... View More
Product Details
PA5-46917
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant canine IL-12/IL-23 p40 Ile23-Ser329
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2607650
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintenance and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CLMF p40; cytotoxic lymphocyte maturation factor 35 kDa subunit; Cytotoxic lymphocyte maturation factor 40 kDa subunit; il 12; IL 12/IL 23p40; il 23; IL 23 p40; IL-12 subunit p35; IL-12 subunit p40; IL-12B; IL12 p40; IL23; il23; IL23 p41; ILN; Interleukin; Interleukin 12; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin 12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 p35 subunit; interleukin-12 p40 subunit; Interleukin-12 subunit beta; Interleukin12; RP23-388G23.1
Gene Aliases: CLMF p35; IL12B
UniProt ID: (Dog) Q28268
Entrez Gene ID: (Dog) 403977, (Dog) 403976, (Dog) 481110
immune response
cytokine-mediated signaling pathway
natural killer cell activation
positive regulation of natural killer cell activation
T-helper cell differentiation
positive regulation of activated T cell proliferation
positive regulation of interferon-gamma biosynthetic process
positive regulation of lymphocyte proliferation
positive regulation of NK T cell activation
response to lipopolysaccharide
positive regulation of interferon-gamma production
positive regulation of T cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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