Invitrogen

IL-12/IL-23 p40 Monoclonal Antibody (CC326)

View all (43) IL-12/IL-23 p40 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-28463

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-

Functional Assay (Functional)

Assay-dependent
-
Product Specifications

Species Reactivity

Bovine

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

CC326

Immunogen

Recombinant bovine IL-12

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2745424

Product Specific Information

Mouse anti Bovine Interleukin-12/23 antibody, clone CC326 recognizes the p40 subunit of bovine interleukin-12.

Target Information

IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintenance and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CLMF p35; CLMF p40; Cytotoxic lymphocyte maturation factor 35 kDa subunit; Cytotoxic lymphocyte maturation factor 40 kDa subunit; il 12; IL 12/IL 23p40; il 23; IL 23 p40; IL-12 subunit p35; IL-12 subunit p40; IL-12A; IL-12B; IL12 p40; IL23; il23; IL23 p41; ILN; Interleukin; Interleukin 12; interleukin 12 35kDa subunit; interleukin 12 40kDa subunit; interleukin 12 polypeptide 35; Interleukin-12 subunit alpha; Interleukin-12 subunit beta; interleukin-23 subunit alpha; Interleukin12; natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35; RP23-388G23.1

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Gene Aliases: BOS_1122; BOS_5471; BOS_8400; Il-12 p35; IL-23; IL12A; IL12B; IL12p35; IL12p40

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UniProt ID: (Bovine) P54349, (Bovine) P46282

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Entrez Gene ID: (Bovine) 281856, (Bovine) 281857, (Bovine) 511022

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Function(s)
cytokine activity interleukin-12 receptor binding protein binding growth factor activity interleukin-12 beta subunit binding interleukin-27 binding protein heterodimerization activity cytokine receptor activity interleukin-12 alpha subunit binding protein homodimerization activity interleukin-23 receptor binding
Process(es)
positive regulation of T cell mediated cytotoxicity positive regulation of defense response to virus by host positive regulation of T-helper 1 type immune response positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target negative regulation of inflammatory response to antigenic stimulus cell cycle arrest response to UV-B positive regulation of activation of JAK2 kinase activity cell migration natural killer cell activation negative regulation of interleukin-10 production negative regulation of interleukin-17 production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of tumor necrosis factor production positive regulation of natural killer cell proliferation positive regulation of smooth muscle cell apoptotic process T-helper cell differentiation interferon-gamma biosynthetic process positive regulation of activated T cell proliferation regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of tyrosine phosphorylation of Stat4 protein positive regulation of tyrosine phosphorylation of Stat5 protein defense response to protozoan negative regulation of growth of symbiont in host positive regulation of osteoclast differentiation positive regulation of cell adhesion negative regulation of smooth muscle cell proliferation defense response to Gram-negative bacterium positive regulation of NK T cell proliferation defense response to virus cellular response to lipopolysaccharide cellular response to interferon-gamma response to virus response to lipopolysaccharide positive regulation of natural killer cell activation positive regulation of T cell differentiation defense response to Gram-positive bacterium positive regulation of NK T cell activation
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