Proteintech

IL-17 Polyclonal Antibody

IL-17 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 6

IL-17 Antibody (13082-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using 13082-1-AP (IL-17 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Product Image Gallery

Product Details

13082-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 17 publications 17 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 6 publications 6 publications

Flow Cytometry (Flow)

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 2 publications 2 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IL-17 Fusion Protein Ag3733 (1-155 aa encoded by BC067505)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.34 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody got 32-35 kDa band in western blot, maybe due to homodimer formation and differential glycosylations.

Immunogen sequence: MTPGKTSLV SLLLLLSLEA IVKAGITIPR NPGCPNSEDK NFPRTVMVNL NIHNRNTNTN PKRSSDYYNR STSPWNLHRN EDPERYPSVI WEAKCRHLGC INADGNVDYH MNSVPIQQEI LVLRREPPHC PNSFRLEKIL VSVGCTCVTP IVHHVA (1-155 aa encoded by B C067505)

Target Information

Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Peng Q,Zhao B,Lin J,Liu H,Zhou R,Lan D,Yao C,Cong S,Tao S,Zhu Y,Wang R,Qi S

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The role of IP-10 and its receptor CXCR3 in early pregnancy.

Molecular immunology

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Canadian journal of gastroenterology & hepatology

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Diagnostic pathology

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Archives of oral biology

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IL-17 Promotes Scar Formation by Inducing Macrophage Infiltration.

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IL-17 Promotes Scar Formation by Inducing Macrophage Infiltration.

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IL-17 Promotes Scar Formation by Inducing Macrophage Infiltration.

The American journal of pathology

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IL-17 Promotes Scar Formation by Inducing Macrophage Infiltration.

The American journal of pathology

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Sun Jul 01 00:00:00 UTC 2018

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Interleukin-17A Plays the Same Role on Mice Acute Lung Injury Respectively Induced by Lipopolysaccharide and Paraquat.

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Sun Oct 01 00:00:00 UTC 2017

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Mon May 21 00:00:00 UTC 2018

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Prevalence of Th17 and Treg cells in gastric cancer patients and its correlation with clinical parameters.

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Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban

Xie S,Ding L,Xiong Z,Zhu S

Fri Jun 01 00:00:00 UTC 2012

Implications of Th1 and Th17 cells in pathogenesis of oral lichen planus.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban

Xie S,Ding L,Xiong Z,Zhu S

Fri Jun 01 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; IL-17; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); Interleukin-17A; Interleukin17A; R-IL-17-A

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Gene Aliases: CTLA-8; CTLA8; IL-17; IL-17A; IL17; IL17A

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UniProt ID: (Human) Q16552

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Entrez Gene ID: (Human) 3605

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Function(s)

cytokine activity cytokine receptor binding protein binding

Process(es)

apoptotic process inflammatory response immune response cell surface receptor signaling pathway cell-cell signaling cell death positive regulation of necrotic cell death positive regulation of interleukin-23 production response to amino acid positive regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter defense response to fungus cellular response to interleukin-1 cellular response to glucocorticoid stimulus fibroblast activation positive regulation of cytokine production involved in inflammatory response positive regulation of interleukin-6 secretion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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IL-17 Polyclonal Antibody

IL-17 Antibody (13082-1-AP) in IHC (P)

Product Details

13082-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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