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Invitrogen
IL-17AF Monoclonal Antibody (1402nAF), Functional Grade, eBioscience™
Product Details
16-9172-38
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a, kappa
Recommended Isotype Control
Class
Monoclonal
Type
Antibody
Clone
1402nAF
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
no preservative
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2866341
Product Specific Information
Description: The 1402nAF monoclonal antibody reacts with mouse interleukin (IL)-17AF heterodimer. This antibody specifically reacts with this heterodimer and has no reactivity for IL-17A or IL-17F homodimers.
Applications Reported: This 1402nAF antibody has been reported for use as a neutralization antibody of IL-17AF biological activity.
Applications Tested: The Functional Grade purified format of the 1402nAF antibody has been tested for neutralization of IL-17AF biological activity.
Storage and handling: Use in a sterile environment.
Filtration: 0.2 µm post-manufacturing filtered.
Purity: Greater than 90%, as determined by SDS-PAGE.
Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.
Aggregation: Less than 10%, as determined by HPLC.
Target Information
IL-17A and IL-17F are well-characterized homodimeric cytokines secreted by T helper 17 (Th17) cells, gamma-delta T cells and several subsets of innate lymphoid cells. Somewhat less appreciated, IL-17A and IL-17F subunits can also form the heterodimer, IL-17AF. Together, these three dimers signal through the IL-17RA/IL-17RC receptor complex to mediate immune responses at mucosal interfaces and are found at lesion sites in inflammatory bowel disease, asthma, atopic dermatitis and rheumatoid arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8; il 17; IL-17; IL-17F; ILN; Interleukin; Interleukin-17A; Interleukin-17F
Gene Aliases: C87042; Ctla-8; Ctla8; IL-17; IL-17A; IL-17F; Il17; Il17a; Il17f
UniProt ID: (Mouse) Q62386, (Mouse) Q7TNI7
Entrez Gene ID: (Mouse) 16171, (Mouse) 257630
inflammatory response
positive regulation of necrotic cell death
positive regulation of interleukin-23 production
positive regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
cellular response to interleukin-1
cellular response to glucocorticoid stimulus
fibroblast activation
positive regulation of cytokine production involved in inflammatory response
proteoglycan metabolic process
negative regulation of angiogenesis
regulation of transforming growth factor beta receptor signaling pathway
cytokine biosynthetic process
lymphotoxin A biosynthetic process
regulation of interleukin-2 biosynthetic process
regulation of interleukin-6 biosynthetic process
regulation of interleukin-8 biosynthetic process
regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
cartilage development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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