Proteintech

IL-17a Polyclonal Antibody

IL-17a Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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IL-17a Antibody (26163-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 26163-1-AP (Il17a Antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

26163-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Il17a Fusion Protein Ag24087

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

320 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

MicroRNAs of extracellular vesicles derived from mesenchymal stromal cells alleviate inflammation in dry eye disease by targeting the IRAK1/TAB2/NF-κB pathway.

The ocular surface

Wang L,Wang X,Chen Q,Wei Z,Xu X,Han D,Zhang Y,Chen Z,Liang Q

Sat Apr 01 00:00:00 UTC 2023

Triptolide alleviates collagen-induced arthritis in mice by modulating Treg/Th17 imbalance through the JAK/PTEN-STAT3 pathway.

Basic & clinical pharmacology & toxicology

Huang Y,Ba X,Wang H,Shen P,Han L,Lin W,Yan J,Chen Z,Tu S

Sat Jul 01 00:00:00 UTC 2023

NEK2 overexpression aggravates IL-22-induced keratinocyte proliferation and cytokine level increases and IMQ-induced psoriasis-like dermatitis.

Biochimica et biophysica acta. Molecular cell research

Peng Y,Zhang Y,Luo M,Pan Y,Zhou R,Yan YN,Yi T,Luo F,Wang B,Wang L,Ran C,Wang H

Fri Dec 01 00:00:00 UTC 2023

Neutrophil-derived interleukin-17A participates in neuroinflammation induced by traumatic brain injury.

Neural regeneration research

Xu XJ,Ge QQ,Yang MS,Zhuang Y,Zhang B,Dong JQ,Niu F,Li H,Liu BY

Mon May 01 00:00:00 UTC 2023

Allicin ameliorates imiquimod-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A.

British journal of pharmacology

Zhang L,Ma X,Shi R,Zhang L,Zhao R,Duan R,Qin Y,Gao S,Li X,Duan J,Li J

Wed Mar 01 00:00:00 UTC 2023

Leptin receptor antagonist attenuates experimental autoimmune thyroiditis in mice by regulating Treg/Th17 cell differentiation.

Frontiers in endocrinology

Wang W,Zhang BT,Jiang QL,Zhao HQ,Xu Q,Zeng Y,Xu JY,Jiang J

Tue Nov 08 00:00:00 UTC 2022

Periodontal ligament cells under mechanical force regulate local immune homeostasis by modulating Th17/Treg cell differentiation.

Clinical oral investigations

Lin J,Huang J,Zhang Z,Yu X,Cai X,Liu C

Fri Apr 01 00:00:00 UTC 2022

Oral Microbiota from Periodontitis Promote Oral Squamous Cell Carcinoma Development via γδ T Cell Activation.

mSystems

Wei W,Li J,Shen X,Lyu J,Yan C,Tang B,Ma W,Xie H,Zhao L,Cheng L,Deng Y,Li Y

Wed Oct 26 00:00:00 UTC 2022

Interleukin-17A mediates tobacco smoke-induced lung cancer epithelial-mesenchymal transition through transcriptional regulation of ΔNp63α on miR-19.

Cell biology and toxicology

Xie C,Zhu J,Huang C,Yang X,Wang X,Meng Y,Geng S,Wu J,Shen H,Hu Z,Meng Z,Li X,Zhong C

Fri Apr 01 00:00:00 UTC 2022

Meningitic Escherichia coli-Induced Interleukin-17A Facilitates Blood-Brain Barrier Disruption via Inhibiting Proteinase 3/Protease-Activated Receptor 2 Axis.

Frontiers in cellular neuroscience

Xu B,Chen J,Fu J,Yang R,Yang B,Huo D,Tan C,Chen H,Wang X

Tue Mar 01 00:00:00 UTC 2022

The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked to Semaphorin5A.

Biomolecules

Lobna M,Nasren E,Adi S,Jacob B,Maria GA,Marcus M,Zahava V

Tue Mar 02 00:00:00 UTC 2021

IL-17 Aggravates Pseudomonas aeruginosa Airway Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease.

Frontiers in immunology

Ding F,Han L,Fu Q,Fan X,Tang R,Lv C,Xue Y,Tian X,Zhang M

Mon Mar 07 00:00:00 UTC 2022

Critical Role of AdipoR1 in Regulating Th17 Cell Differentiation Through Modulation of HIF-1α-Dependent Glycolysis.

Frontiers in immunology

Zhang Q,Wang L,Jiang J,Lin S,Luo A,Zhao P,Tan W,Zhang M

Fri Apr 30 00:00:00 UTC 2021

Ozone therapy promotes the differentiation of basal keratinocytes via increasing Tp63-mediated transcription of KRT10 to improve psoriasis.

Journal of cellular and molecular medicine

Gao L,Dou J,Zhang B,Zeng J,Cheng Q,Lei L,Tan L,Zeng Q,Ding S,Guo A,Cheng H,Yang C,Luo Z,Lu J

Wed Apr 01 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8; il 17; IL-17; ILN; Interleukin; interleukin 17; Interleukin-17A; Interleukin17A; R-IL-17-A

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Gene Aliases: Ctla-8; Ctla8; IL-17; IL-17A; Il17; Il17a

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UniProt ID: (Mouse) Q62386

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Entrez Gene ID: (Mouse) 16171

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Function(s)

cytokine activity

Process(es)

inflammatory response positive regulation of necrotic cell death positive regulation of interleukin-23 production positive regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter cellular response to interleukin-1 cellular response to glucocorticoid stimulus fibroblast activation positive regulation of cytokine production involved in inflammatory response

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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IL-17a Polyclonal Antibody

IL-17a Antibody (26163-1-AP) in IHC (P)

Product Details

26163-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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