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IL-22 Receptor alpha Antibody (PA5-144626) in ICC/IF
Immunocytochemistry analysis of IL-22 Receptor alpha in SiHa cells (green). Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 10% negative goat serum for 15 minutes at room temperature. Cells were incubated with IL-22 Receptor alpha polyclonal antibody (Product # PA5-144626) with a dilution of 1:200 for 1 hour at room temperature, washe... View More
Product Details
PA5-144626
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within human IL-22RA1 aa 1-50/574.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.05% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3093527
Product Specific Information
Positive control: 293T cell lysate, HepG2 cell lysate, K562 cell lysate, Hela, SiHa, mouse kidney tissue, rat pancreas tissue.
Predicted band size: 63 kDa
Subcellular Location: Membrane.
Target Information
A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CRF2-9; Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; il-22 receptor; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; ILN; Interleukin; interleukin 22 receptor, alpha 1; interleukin-22 receptor alpha chain; Interleukin-22 receptor subunit alpha-1; ZcytoR11
Gene Aliases: 9130219A07Rik; CRF2-9; ENSMUSG00000073746; IL-22R; IL22R; IL22R1; IL22RA1; RGD1559655
UniProt ID: (Human) Q8N6P7, (Mouse) Q80XZ4
Entrez Gene ID: (Human) 58985, (Mouse) 230828, (Rat) 362629
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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