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Invitrogen
IL-34 Polyclonal Antibody
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IL-34 Antibody (PA5-95624) in IHC (P)
Immunohistochemistry analysis of IL-34 in paraffin-embedded human tonsil tissue. Antigen retrieval was performed on the tissue using citrate buffer (pH 6, 20 min) and blocked with 10% goat serum. Samples were incubated with IL-34 polyclonal antibody (Product # PA5-95624) at a 1 µg/mL dilution, followed by biotinylated goat anti-rabbit IgG (30 min, 37°C), and developed with Strepavidin-Biotin-Complex and DAB... View More
Product Details
PA5-95624
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence of human Interleukin 34/IL34 (NEPLEMWPLTQNEECTVTGFLRDKLQYR).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2807426
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human HepG2 whle cell, human A549 whole cell, human SH-SY5Y whole cell, human U87 whole cell, human CACO-2 whole cell, human U20S whole cell, human HEK293 whole cell, rat C6 whole cell,mouse ANA-1 whole cell. IHC: mhuman liver cancer tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
IL-34 is secreted as a dimeric protein and currently belongs to no known cytokine family. It signals via the M-CSF Receptor, also known as CSF-1R and CD115, which is shared with M-CSF. IL-34 has no amino acid sequence homology to M-CSF, but they exhibit similarities in secondary structure and share overlapping functions. IL-34 has been shown to promote myeloid survival, proliferation, and differentiation, and to play a role in osteoclast formation. IL-34 expression has been detected in various tissues and is most abundant in the spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: IL-34; ILN; Interleukin; Interleukin-34; Interleukin34
Gene Aliases: 2010004A03Rik; AI593503; C16orf77; IL-34; IL34
UniProt ID: (Human) Q6ZMJ4, (Mouse) Q8R1R4, (Rat) Q4KM46
Entrez Gene ID: (Human) 146433, (Mouse) 76527, (Rat) 498951
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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