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Invitrogen
IL-6 Receptor Recombinant Rabbit Monoclonal Antibody (033)
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IL-6 Receptor Antibody (MA5-29721) in WB
Western blot was performed using Anti-IL-6 Receptor Recombinant Rabbit Monoclonal Antibody (33) (Product # MA5-29721) and a 70kDa band corresponding to full length Interleukin-6 receptor subunit alpha, and a 55kDa band corresponding to secretory Interleukin-6 receptor alpha was observed across all cell lines and tissues tested. Membrane enriched extracts (30 µg lysate) of Mouse Spleenocytes (Lane 1), RAW 264.7 (Lane 2) and RAW 264.7 conditioned medium (Lane 3) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321B... View More
Product Details
MA5-29721
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
033
Immunogen
Recombinant Mouse IL-6R/CD126 protein (Ile44-Glu357)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2785544
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Mouse IL-6R/CD126.
Target Information
Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD126; CD126 antigen; gp80; IL-6 Receptor; il-6 receptor alpha; IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; ILN; Interleukin; interleukin 6 receptor, alpha; Interleukin-6 receptor subunit alpha; Membrane glycoprotein 80; MGC104991
Gene Aliases: CD126; gp80; IL-6R-1; IL-6RA; IL6Q; IL6R; IL6R1; IL6RA; IL6RQ
UniProt ID: (Human) P08887
Entrez Gene ID: (Human) 3570, (Rat) 24499
positive regulation of cell proliferation
response to gamma radiation
positive regulation of activation of Janus kinase activity
cell growth
cytokine-mediated signaling pathway
endocrine pancreas development
response to lipopolysaccharide
negative regulation of interleukin-8 production
positive regulation of chemokine production
positive regulation of interleukin-6 production
negative regulation of collagen biosynthetic process
response to cytokine
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of MAPK cascade
response to peptide hormone
response to ethanol
positive regulation of JAK-STAT cascade
positive regulation of smooth muscle cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
positive regulation of NF-kappaB transcription factor activity
response to glucocorticoid
response to cAMP
interleukin-6-mediated signaling pathway
ciliary neurotrophic factor-mediated signaling pathway
hepatic immune response
monocyte chemotaxis
positive regulation of leukocyte chemotaxis
acute-phase response
positive regulation of osteoblast differentiation
extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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