Invitrogen

IL-6 Receptor Monoclonal Antibody (B-R6)

IL-6 Receptor Antibody in Immunocytochemistry (ICC/IF)

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IL-6 Receptor Antibody (MA1-80456) in ICC/IF

International journal of molecular sciences 2022 - Figure 1 IL11 induces pancreatic stellate cell activation and invasion. ( a ) t-distributed stochastic neighbour embedding (tSNE) plots showing scRNA-seq expression of Il11ra1 , Il6ra and Il-6st ( gp130 ) in mouse pancreatic tissue. Cell clusters were identified using the Tabula Muris web tool ( https://tabula-muris.ds.czbiohub.org/ (accessed on 21 February 2022)). []. Black arrows indicate pancreatic stell... View More

IL-6 Receptor Antibody in Immunohistochemistry (IHC)

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Product Details

MA1-80456

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent

Immunocytochemistry (ICC/IF)

Assay-dependent

View 1 publication 1 publication

Flow Cytometry (Flow)

1:50

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

View 1 publication 1 publication

Immunoprecipitation (IP)

Assay-dependent

Neutralization (Neu)

View 2 publications 2 publications

Miscellaneous PubMed (MISC)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

B-R6

Immunogen

CHO cells transfected with cDNA of the IL-6 receptor.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

<0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2249244

Product Specific Information

For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.

Mouse anti Human CD126 antibody, clone B-R6 recognizes human Interleukin-6 receptor subunit alpha, also known as CD126, IL-6R or Membrane glycoprotein 80.

Target Information

Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis.

International journal of molecular sciences

Ng B,Viswanathan S,Widjaja AA,Lim WW,Shekeran SG,Goh JWT,Tan J,Kuthubudeen F,Lim SY,Xie C,Schafer S,Adami E,Cook SA

MA1-80456 was used in Immunocytochemistry to describe the IL11-mediated activation of PSCs and suggest IL11 as a stromal therapeutic target in pancreatitis.

Thu Mar 24 00:00:00 UTC 2022

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH.

Nature communications

Dong J,Viswanathan S,Adami E,Singh BK,Chothani SP,Ng B,Lim WW,Zhou J,Tripathi M,Ko NSJ,Shekeran SG,Tan J,Lim SY,Wang M,Lio PM,Yen PM,Schafer S,Cook SA,Widjaja AA

MA1-80456 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation to show that IL11 modulates hepatocyte metabolism and suggests a mechanism for NAFLD to NASH transition.

Mon Jan 04 00:00:00 UTC 2021

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH.

Nature communications

Dong J,Viswanathan S,Adami E,Singh BK,Chothani SP,Ng B,Lim WW,Zhou J,Tripathi M,Ko NSJ,Shekeran SG,Tan J,Lim SY,Wang M,Lio PM,Yen PM,Schafer S,Cook SA,Widjaja AA

Mon Jan 04 00:00:00 UTC 2021

Involvement of hepcidin in the anemia of multiple myeloma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Sharma S,Nemeth E,Chen YH,Goodnough J,Huston A,Roodman GD,Ganz T,Lichtenstein A

MA1-80456 was used in blocking or activating experiment to investigate the role of hepcidin in the anemia of multiple myeloma

Sun Jun 01 00:00:00 UTC 2008

Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity.

Experimental cell research

Thyrell L,Arulampalam V,Hjortsberg L,Farnebo M,Grandér D,Pokrovskaja Tamm K

MA1-80456 was used in blocking or activating experiment to establish that IFNalpha treatment results in reduced STAT3 activity in two myeloma cell lines, U266-1984 and U-1958

Thu Nov 15 00:00:00 UTC 2007

Retinoic acid inhibits IL-6-dependent but not constitutive STAT3 activation in Epstein-Barr virus-immortalized B lymphocytes.

International journal of oncology

Zancai P,Cariati R,Quaia M,Guidoboni M,Rizzo S,Boiocchi M,Dolcetti R

MA1-80456 was used in flow cytometry to evaluate the effects of retinoic acid on IL-6 signaling in lymphoblastoid B-cell lines

Sun Aug 01 00:00:00 UTC 2004

Interleukin-6 enhances whereas tumor necrosis factor alpha and interferons inhibit integrin expression and adhesion of human mast cells to extracellular matrix proteins.

The Journal of investigative dermatology

Schoeler D,Grützkau A,Henz BM,Küchler J,Krüger-Krasagakis S

MA1-80456 was used in flow cytometry to assess the effects of cytokines on integrin expression and mast cell adhesion.

Thu May 01 00:00:00 UTC 2003

Human herpesvirus 8-encoded interleukin 6 activates HIV-1 in the U1 monocytic cell line.

AIDS (London, England)

Gage JR,Breen EC,Echeverri A,Magpantay L,Kishimoto T,Miles S,Martínez-Maza O

MA1-80456 was used in ELISA to study human herpesvirus 8 interleukin 6.

Fri Oct 01 00:00:00 UTC 1999

Selective proteolytic cleavage of IL-2 receptor and IL-6 receptor ligand binding chains by neutrophil-derived serine proteases at foci of inflammation.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

Bank U,Reinhold D,Schneemilch C,Kunz D,Synowitz HJ,Ansorge S

MA1-80456 was used in flow cytometry to examine the role of role of neutrophil-derived serine proteases in traumatic brain injuries.

Mon Nov 01 00:00:00 UTC 1999

Bioinformatics

Protein Aliases: CD126; CD126 antigen; gp80; IL-6 Receptor; il-6 receptor alpha; IL-6 receptor subunit alpha; IL-6R 1; ILN; Interleukin; Interleukin-6 receptor subunit alpha; Membrane glycoprotein 80; MGC104991

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Gene Aliases: CD126; gp80; IL-6R-1; IL-6RA; IL6Q; IL6R; IL6RA; IL6RQ

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UniProt ID: (Human) P08887

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Entrez Gene ID: (Human) 3570

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Function(s)

ciliary neurotrophic factor receptor activity interleukin-6 receptor activity interleukin-6 receptor binding protein binding enzyme binding interleukin-6 binding protein homodimerization activity ciliary neurotrophic factor binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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IL-6 Receptor Monoclonal Antibody (B-R6)

IL-6 Receptor Antibody (MA1-80456) in ICC/IF

Product Details

MA1-80456

Immunohistochemistry (IHC)

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

ELISA (ELISA)

Immunoprecipitation (IP)

Neutralization (Neu)

Miscellaneous PubMed (MISC)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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