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Invitrogen
IL1RA Polyclonal Antibody
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IL1RA Antibody (PA5-95748) in WB
Western blot analysis of IL1RA in extracts of mouse pancreas. Samples were incubated with IL1RA Polyclonal antibody (Product # PA5-95748) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-95748
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-159 of human IL1RA (NP_0005681)
Conjugate
Form
Liquid
Concentration
0.88 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2807550
Product Specific Information
Immunogen sequence: MALETICRPS GRKSSKMQAF RIWDVNQKTF YLRNNQLVAG YLQGPNVNLE EKIDVVPIEP HALFLGIHGG KMCLSCVKSG DETRLQLEAV NITDLSENRK QDKRFAFIRS DSGPTTSFES AACPGWFLCT AMEADQPVSL TNMPDEGVMV TKFYFQEDE; Positive Samples: Mouse pancreas; Cellular Location: Cytoplasm
Target Information
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD121A; D2S1473; IL 1 receptor antagonist; il-1 receptor; il-1r; IL-1R-alpha; IL-1RN; IL1 inhibitor; il1 receptor; IL1 receptor antagonist; IL1-RA; IL1R; IL1RN (IL1F3); interleukin-1 receptor; Interleukin-1 receptor antagonist protein; IRAP; MGC10430; P80
Gene Aliases: F630041P17Rik; IL-1ra; Il1rn
UniProt ID: (Mouse) P25085, (Rat) P25086
Entrez Gene ID: (Mouse) 16181, (Rat) 60582
fever generation
negative regulation of cytokine-mediated signaling pathway
lipid metabolic process
acute-phase response
memory
negative regulation of glutamate secretion
cytokine-mediated signaling pathway
sensory perception of pain
insulin secretion
negative regulation of cell migration
negative regulation of heterotypic cell-cell adhesion
negative regulation of apoptotic process
positive regulation of JUN kinase activity
negative regulation of membrane potential
response to glucocorticoid
extracellular negative regulation of signal transduction
negative regulation of receptor activity
negative regulation of interleukin-1-mediated signaling pathway
chronic inflammatory response to antigenic stimulus
female pregnancy
negative regulation of signal transduction
response to organonitrogen compound
response to organic cyclic compound
response to activity
carboxylic acid metabolic process
response to lipopolysaccharide
response to drug
response to starvation
response to interleukin-1
response to interleukin-4
cellular response to norepinephrine stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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