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IL1RAPL1 Antibody (PA5-96244) in WB
Western blot analysis of IL1RAPL1 in extracts of various cell lines. Samples were incubated with IL1RAPL1 Polyclonal antibody (Product # PA5-96244) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-96244
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 130-210 of human IL1RAPL1 (NP_0550861)
Conjugate
Form
Liquid
Concentration
3.07 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2808046
Product Specific Information
Immunogen sequence: SISLTVGEND TGLCYNSKMK YFEKAELSKS KEISCRDIED FLLPTREPEI LWYKECRTKT WRPSIVFKRD TLLIREVRED D; Positive Samples: A-431, Mouse brain, Mouse heart, Rat brain, Rat heart; Cellular Location: Cell membrane, Cell projection, Cytoplasm, Single-pass type I membrane protein, axon, dendrite
Target Information
The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signaling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; interleukin 1 receptor accessory protein-like 1; interleukin 1 receptor-8; Interleukin-1 receptor accessory protein-like 1; mental retardation, X-linked 10; Oligophrenin-4; Three immunoglobulin domain-containing IL-1 receptor-related 2; TIGIRR-2; X-linked interleukin-1 receptor accessory protein-like 1
Gene Aliases: 6330532G10Rik; C030039N24; IL1R8; IL1RAPL; IL1RAPL1; MRX10; MRX21; MRX34; OPHN4; TIGIRR-2
UniProt ID: (Human) Q9NZN1, (Rat) P59824
Entrez Gene ID: (Human) 11141, (Mouse) 331461, (Rat) 317553
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
signal transduction
regulation of neuron projection development
neuron differentiation
regulation of ion transmembrane transport
negative regulation of exocytosis
positive regulation of dendrite morphogenesis
calcium ion transmembrane transport
presynaptic membrane assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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