Proteintech

IL22RA1 Polyclonal Antibody

IL22RA1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 6

IL22RA1 Antibody (13462-1-AP) in ICC/IF

Immunofluorescent analysis of COLO 320 cells using 13462-1-AP (IL22RA1 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

IL22RA1 Antibody in Flow Cytometry (Flow)

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Product Details

13462-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:10-1:100

View 2 publications 2 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IL22RA1 Fusion Protein Ag4056 (253-574 aa encoded by BC029273)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.53 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: YVTKPPAPP NSLNVQRVLT FQPLRFIQEH VLIPVFDLSG PSSLAQPVQY SQIRVSGPRE PAGAPQRHSL SEITYLGQPD ISILQPSNVP PPQILSPLSY APNAAPEVGP PSYAPQVTPE AQFPFYAPQA ISKVQPSSYA PQATPDSWPP SYGVCMEGSG KDSPTGTLSS PKHLRPKGQL QKEPPAGSCM LGGLSLQEVT SLAMEESQEA KSLHQPLGIC TDRTSDPNVL HSGEEGTPQY LKGQLPLLSS VQIEGHPMSL PLQPPSRPCS PSDQGPSPWG LLESLVCPKD EAKSPAPETS DLEQPTELDS LFRGLALTVQ WES (253-574 aa encoded by BC029273)

Target Information

A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Troxerutin attenuates insulin resistance via pancreatic IL-22/JAK1/STAT3 signaling activation in dihydrotestosterone-induced polycystic ovary syndrome rats.

American journal of physiology. Endocrinology and metabolism

Gao Z,Wang G,Ma X,Tan H,Zhang C,Yin X,Suo F,Yao R,Yan X

Tue Nov 01 00:00:00 UTC 2022

Troxerutin attenuates insulin resistance via pancreatic IL-22/JAK1/STAT3 signaling activation in dihydrotestosterone-induced polycystic ovary syndrome rats.

American journal of physiology. Endocrinology and metabolism

Gao Z,Wang G,Ma X,Tan H,Zhang C,Yin X,Suo F,Yao R,Yan X

Tue Nov 01 00:00:00 UTC 2022

Th22 cells induce Müller cell activation via the Act1/TRAF6 pathway in diabetic retinopathy.

Cell and tissue research

Wang Y,Yu H,Li J,Liu W,Yu S,Lv P,Zhao L,Wang X,Zuo Z,Liu X

Thu Dec 01 00:00:00 UTC 2022

IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo.

Oxidative medicine and cellular longevity

Bai Y,Wu H,Zhang J,Zhang S,Zhang Z,Wang H,Zhang Y,Shen Z

Mon May 23 00:00:00 UTC 2022

IL-22 ameliorated cardiomyocyte apoptosis in cardiac ischemia/reperfusion injury by blocking mitochondrial membrane potential decrease, inhibiting ROS and cytochrome C.

Biochimica et biophysica acta. Molecular basis of disease

Che Y,Tian Y,Chen R,Xia L,Liu F,Su Z

Wed Sep 01 00:00:00 UTC 2021

The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.

Life sciences

Wu S,Zhao M,Sun Y,Xie M,Le K,Xu M,Huang C

Wed Jan 15 00:00:00 UTC 2020

Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax.

Apoptosis : an international journal on programmed cell death

Wang B,Han D,Li F,Hou W,Wang L,Meng L,Mou K,Lu S,Zhu W,Zhou Y

Thu Oct 01 00:00:00 UTC 2020

Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22.

PLoS biology

Chen Y,Vandereyken M,Newton IP,Moraga I,Näthke IS,Swamy M

Fri Nov 01 00:00:00 UTC 2019

HMGB1-induced autophagy facilitates hepatic stellate cells activation: a new pathway in liver fibrosis.

Clinical science (London, England : 1979)

Li J,Zeng C,Zheng B,Liu C,Tang M,Jiang Y,Chang Y,Song W,Wang Y,Yang C

Thu Aug 16 00:00:00 UTC 2018

HMGB1-induced autophagy facilitates hepatic stellate cells activation: a new pathway in liver fibrosis.

Clinical science (London, England : 1979)

Li J,Zeng C,Zheng B,Liu C,Tang M,Jiang Y,Chang Y,Song W,Wang Y,Yang C

Thu Aug 16 00:00:00 UTC 2018

Type 3 innate lymphoid cell: a new player in liver fibrosis progression.

Clinical science (London, England : 1979)

Wang S,Li J,Wu S,Cheng L,Shen Y,Ma W,She W,Yang C,Wang J,Jiang W

Fri Dec 21 00:00:00 UTC 2018

Type 3 innate lymphoid cell: a new player in liver fibrosis progression.

Clinical science (London, England : 1979)

Wang S,Li J,Wu S,Cheng L,Shen Y,Ma W,She W,Yang C,Wang J,Jiang W

Fri Dec 21 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: CRF2-9; Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; il-22 receptor; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; ILN; Interleukin; interleukin 22 receptor, alpha 1; interleukin-22 receptor alpha chain; Interleukin-22 receptor subunit alpha-1; ZcytoR11

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Gene Aliases: 9130219A07Rik; CRF2-9; ENSMUSG00000073746; IL-22R; IL22R; IL22R1; IL22RA1; RGD1559655

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UniProt ID: (Human) Q8N6P7, (Mouse) Q80XZ4

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Entrez Gene ID: (Human) 58985, (Mouse) 230828, (Rat) 362629

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Function(s)

interferon receptor activity protein binding interleukin-20 binding cytokine receptor activity molecular_function

Process(es)

cytokine-mediated signaling pathway defense response to Gram-negative bacterium biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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IL22RA1 Polyclonal Antibody

IL22RA1 Antibody (13462-1-AP) in ICC/IF

Product Details

13462-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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