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Immunogen sequence: MDLFGDLPE PERSPRPAAG KEAQKGPLLF DDLPPASSTD SGSGGPLLFD DLPPASSGDS GSLATSISQM VKTEGKGAKR KTSEEEKNGS EELVEKKVCK ASSVIFGLKG YVAERKGERE EMQDAHVILN DITEECRPPS SLITRVSYFA VFDGHGGIRA SKFAAQNLHQ NLIRKFPKGD VISVEKTVKR CLLDTFKHTD EEFLKQASSQ KPAWKDGSTA TCVLAVDNIL YIANLGDSRA ILCRYNEESQ KHAALSLSKE HNPTQYEERM RIQKAGGNVR DGRVLGVLEV SRSIGDGQYK RCGVTSVPDI RRCQLTPNDR FILLACDGLF KVFTPEEAVN FILSCLEDEK IQTREGKSAA DARYEAACNR LANKAVQRGS ADNVTVMVVR IGH (1-392 aa encoded by BC006576)
The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EC 3.1.3.16; ILKAP; integrin-linked kinase associated phosphatase; Integrin-linked kinase-associated serine/threonine phosphatase 2C; PP2Cdelta; protein phosphatase 2C; protein phosphatase 2c, delta isozyme; protein phosphatase, Mg2+/Mn2+ dependent 1O
Gene Aliases: 0710007A14Rik; 1600009O09Rik; ILKAP; ILKAP2; ILKAP3; PP2C-DELTA; PPM1O
UniProt ID: (Human) Q9H0C8, (Mouse) Q8R0F6, (Rat) Q9Z1Z6
Entrez Gene ID: (Human) 80895, (Mouse) 67444, (Rat) 64538
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