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Bioss
IMPACT Polyclonal Antibody
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Product Details
BS-16625R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human IMPACT, amino acids 21-120.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.03% ProClin 300
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Impact homolog; Imprinted and ancient gene protein; Imprinted and ancient gene protein homolog; Protein IMPACT; RWD domain containing 5
Gene Aliases: E430016J11Rik; IMPACT; RWDD5
UniProt ID: (Human) Q9P2X3, (Mouse) O55091, (Rat) Q5GFD9
Entrez Gene ID: (Human) 55364, (Mouse) 16210, (Rat) 497198
negative regulation of protein phosphorylation
regulation of translation
regulation of translational initiation
negative regulation of transcription from RNA polymerase II promoter
biological_process
negative regulation of protein complex assembly
negative regulation of protein autophosphorylation
cellular response to amino acid starvation
cellular response to glucose starvation
positive regulation of neuron differentiation
negative regulation of cell death
regulation of eIF2 alpha phosphorylation by amino acid starvation
cellular response to hydrogen peroxide
positive regulation of translational initiation in response to starvation
cellular response to acidic pH
cellular response to UV-C
cellular response to benomyl
negative regulation of transcription from RNA polymerase II promoter in response to stress
neuron projection extension
cellular response to leucine starvation
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