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IMPDH1 Polyclonal Antibody

IMPDH1 Antibody in Immunocytochemistry (ICC/IF)

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IMPDH1 Antibody (22092-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HeLa cells using 22092-1-AP (IMPDH1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

IMPDH1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IMPDH1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

22092-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IMPDH1 Fusion Protein Ag17297 (170-235 aa encoded by BC033622)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LSPSHTVGD VLEAKMRHGF SGIPITETGT MGSKLVGIVT SRDIDFLAEK DHTTLLSEVM TPRIELV (170-235 aa encoded by BC033622 )

Target Information

The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The Role of Purine Metabolism-Related Genes PPAT and IMPDH1 in the Carcinogenesis of Intrahepatic Cholangiocarcinoma Based on Metabonomic and Bioinformatic Analyses.

Journal of oncology

Liu CJ,Ma ZZ,Gong WZ,Mao XH,Wen HQ,Wang XH

Wed Sep 11 00:00:00 UTC 2024

Characterization of the microenvironment in different immune-metabolism subtypes of cervical cancer with prognostic significance.

Frontiers in genetics

Lai W,Liao J,Li X,Liang P,He L,Huang K,Liang X,Wang Y

Fri Feb 24 00:00:00 UTC 2023

Characterization of the microenvironment in different immune-metabolism subtypes of cervical cancer with prognostic significance.

Frontiers in genetics

Lai W,Liao J,Li X,Liang P,He L,Huang K,Liang X,Wang Y

Fri Feb 24 00:00:00 UTC 2023

LncRNA UCA1 Participates in De Novo Synthesis of Guanine Nucleotides in Bladder Cancer by Recruiting TWIST1 to Increase IMPDH1/2.

International journal of biological sciences

Liu SS,Li JS,Xue M,Wu WJ,Li X,Chen W

Wed May 24 00:00:00 UTC 2023

IMPDH1, a prognostic biomarker and immunotherapy target that correlates with tumor immune microenvironment in pan-cancer and hepatocellular carcinoma.

Frontiers in immunology

Liu C,Zhang W,Zhou X,Liu L

Tue Jan 10 00:00:00 UTC 2023

Distinct Classes of Flavonoids and Epigallocatechin Gallate, Polyphenol Affects an Oncogenic Mutant p53 Protein, Cell Growth and Invasion in a TNBC Breast Cancer Cell Line.

Cells

Kollareddy M,Martinez LA

Fri Apr 02 00:00:00 UTC 2021

Nuclear IMPDH Filaments in Human Gliomas.

Journal of neuropathology and experimental neurology

Ahangari N,Munoz DG,Coulombe J,Gray DA,Engle EC,Cheng L,Woulfe J

Tue Oct 26 00:00:00 UTC 2021

IMPDH1/YB-1 Positive Feedback Loop Assembles Cytoophidia and Represents a Therapeutic Target in Metastatic Tumors.

Molecular therapy : the journal of the American Society of Gene Therapy

Ruan H,Song Z,Cao Q,Ni D,Xu T,Wang K,Bao L,Tong J,Xiao H,Xiao W,Cheng G,Xiong Z,Liang H,Liu D,Wang L,Olivier T,Jane BH,Yang H,Zhang X,Chen K

Wed May 06 00:00:00 UTC 2020

IMPDH1/YB-1 Positive Feedback Loop Assembles Cytoophidia and Represents a Therapeutic Target in Metastatic Tumors.

Molecular therapy : the journal of the American Society of Gene Therapy

Ruan H,Song Z,Cao Q,Ni D,Xu T,Wang K,Bao L,Tong J,Xiao H,Xiao W,Cheng G,Xiong Z,Liang H,Liu D,Wang L,Olivier T,Jane BH,Yang H,Zhang X,Chen K

Wed May 06 00:00:00 UTC 2020

IMPDH1/YB-1 Positive Feedback Loop Assembles Cytoophidia and Represents a Therapeutic Target in Metastatic Tumors.

Molecular therapy : the journal of the American Society of Gene Therapy

Ruan H,Song Z,Cao Q,Ni D,Xu T,Wang K,Bao L,Tong J,Xiao H,Xiao W,Cheng G,Xiong Z,Liang H,Liu D,Wang L,Olivier T,Jane BH,Yang H,Zhang X,Chen K

Wed May 06 00:00:00 UTC 2020

IMPDH1/YB-1 Positive Feedback Loop Assembles Cytoophidia and Represents a Therapeutic Target in Metastatic Tumors.

Molecular therapy : the journal of the American Society of Gene Therapy

Ruan H,Song Z,Cao Q,Ni D,Xu T,Wang K,Bao L,Tong J,Xiao H,Xiao W,Cheng G,Xiong Z,Liang H,Liu D,Wang L,Olivier T,Jane BH,Yang H,Zhang X,Chen K

Wed May 06 00:00:00 UTC 2020

ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis.

Molecular cell

Ali ES,Sahu U,Villa E,O'Hara BP,Gao P,Beaudet C,Wood AW,Asara JM,Ben-Sahra I

Thu Jun 18 00:00:00 UTC 2020

Reference standards for the detection of anti-mitochondrial and anti-rods/rings autoantibodies.

Clinical chemistry and laboratory medicine

Calise SJ,Zheng B,Hasegawa T,Satoh M,Isailovic N,Ceribelli A,Andrade LEC,Boylan K,Cavazzana I,Fritzler MJ,de la Torre IG,Hiepe F,Kohl K,Selmi C,Shoenfeld Y,Tincani A,Chan EKL

Tue Sep 25 00:00:00 UTC 2018

Reference standards for the detection of anti-mitochondrial and anti-rods/rings autoantibodies.

Clinical chemistry and laboratory medicine

Calise SJ,Zheng B,Hasegawa T,Satoh M,Isailovic N,Ceribelli A,Andrade LEC,Boylan K,Cavazzana I,Fritzler MJ,de la Torre IG,Hiepe F,Kohl K,Selmi C,Shoenfeld Y,Tincani A,Chan EKL

Tue Sep 25 00:00:00 UTC 2018

Loukoumasomes Are Distinct Subcellular Structures from Rods and Rings and Are Structurally Associated with MAP2 and the Nuclear Envelope in Retinal Cells.

PloS one

Noble JW,Hunter DV,Roskelley CD,Chan EK,Mills J

Fri Jun 16 00:00:00 UTC 2017

Loukoumasomes Are Distinct Subcellular Structures from Rods and Rings and Are Structurally Associated with MAP2 and the Nuclear Envelope in Retinal Cells.

PloS one

Noble JW,Hunter DV,Roskelley CD,Chan EK,Mills J

Fri Jun 16 00:00:00 UTC 2017

Characterisation of inosine monophosphate dehydrogenase expression during retinal development: differences between variants and isoforms.

The international journal of biochemistry & cell biology

Gunter JH,Thomas EC,Lengefeld N,Kruger SJ,Worton L,Gardiner EM,Jones A,Barnett NL,Whitehead JP

Tue Sep 30 00:00:00 UTC 2008

Characterisation of inosine monophosphate dehydrogenase expression during retinal development: differences between variants and isoforms.

The international journal of biochemistry & cell biology

Gunter JH,Thomas EC,Lengefeld N,Kruger SJ,Worton L,Gardiner EM,Jones A,Barnett NL,Whitehead JP

Tue Sep 30 00:00:00 UTC 2008

Bioinformatics

Protein Aliases: DKFZp781N0678; IMP (inosine 5'-monophosphate) dehydrogenase 1; IMP (inosine monophosphate) dehydrogenase 1; IMP dehydrogenase 1; IMP dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_03156}; IMPD 1; IMPD 1 {ECO:0000255|HAMAP-Rule:MF_03156}; IMPDH 1; IMPDH 1 {ECO:0000255|HAMAP-Rule:MF_03156}; IMPDH-I; inosine 5'-phosphate dehydrogenase 1; inosine monophosphate dehydrogenase 1; Inosine-5'-monophosphate dehydrogenase 1; inosine-5'-monophosphate dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_03156}

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Gene Aliases: B930086D20Rik; IMPD; IMPD 1; IMPD1; IMPDH 1; IMPDH-I; IMPDH1; LCA11; RP10; sWSS2608

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UniProt ID: (Human) B3KVM8, (Mouse) P50096

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Entrez Gene ID: (Human) 3614, (Rat) 362329, (Mouse) 23917

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Function(s)

nucleotide binding nucleic acid binding DNA binding RNA binding IMP dehydrogenase activity metal ion binding molecular_function

Process(es)

purine nucleotide biosynthetic process GMP biosynthetic process response to cold lymphocyte proliferation oxidation-reduction process retina development in camera-type eye purine ribonucleoside monophosphate biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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IMPDH1 Polyclonal Antibody

IMPDH1 Antibody (22092-1-AP) in ICC/IF

Product Details

22092-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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