Proteintech

IMPDH2 Polyclonal Antibody

IMPDH2 Antibody in Immunocytochemistry (ICC/IF)

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IMPDH2 Antibody (12948-1-AP) in ICC/IF

Immunofluorescent analysis of (-20&(8)451; Ethanol) fixed HeLa cells using (Product # 12948-1-AP) (IMPDH2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

IMPDH2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IMPDH2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12948-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,200

View 19 publications 19 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 25 publications 25 publications

ELISA (ELISA)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IMPDH2 Fusion Protein Ag3632 (1-350 aa encoded by BC012840)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MADYLISGG TSYVPDDGLT AQQLFNCGDG LTYNDFLILP GYIDFTADQV DLTSALTKKI TLKTPLVSSP MDTVTEAGMA IAMALTGGIG FIHHNCTPEF QANEVRKVKK YEQGFITDPV VLSPKDRVRD VFEAKARHGF CGIPITDTGR MGSRLVGIIS SRDIDFLKEE EHDCFLEEIM TKREDLVVAP AGITLKEANE ILQRSKKGKL PIVNEDDELV AIIARTDLKK NRDYPLASKD AKKQLLCGAA IGTHEDDKYR LDLLAQAGVD VVVLDSSQGN SIFQINMIKY IKDKYPNLQV IGGNVVTAAQ AKNLIDAGVD ALRVGMGSGS ICITQEVLAC GRPQATAVYK V (1-350 aa encoded by BC012840)

Target Information

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Circular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer.

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SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptome.

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'Rod and ring' formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway.

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Fri Aug 01 00:00:00 UTC 2014

Glutamine deprivation initiates reversible assembly of mammalian rods and rings.

Cellular and molecular life sciences : CMLS

Calise SJ,Carcamo WC,Krueger C,Yin JD,Purich DL,Chan EK

Fri Aug 01 00:00:00 UTC 2014

Glutamine deprivation initiates reversible assembly of mammalian rods and rings.

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Ultrastructure of cytoplasmic and nuclear inosine-5'-monophosphate dehydrogenase 2 "rods and rings" inclusions.

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Tue Apr 01 00:00:00 UTC 2014

Molecular cell biology and immunobiology of mammalian rod/ring structures.

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Carcamo WC,Calise SJ,von Mühlen CA,Satoh M,Chan EK

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The Journal of clinical investigation

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Fri Nov 01 00:00:00 UTC 2013

Hirschsprung-like disease is exacerbated by reduced de novo GMP synthesis.

The Journal of clinical investigation

Lake JI,Tusheva OA,Graham BL,Heuckeroth RO

Fri Nov 01 00:00:00 UTC 2013

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Tue Jan 15 00:00:00 UTC 2013

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