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Product Details
10896-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: YLEHYLDSIE NLPFELQRNF QLMRDLDQRT EDLKAEIDKL ATEYMSSARS LSSEEKLALL KQIQEAYGKC KEFGDDKVQL AMQTYEMVDK HIRRLDTDLA RFEADLKEKQ IESSDYDSSS SKGKKSRTQK EKKAARARSK GKNSDEEAPK TAQKKLKLVR TSPEYGMPSV TFGSVHPSDV LDMPVDPNEP TYCLCHQVSY GEMIGCDNPD CSIEWFHFAC VGLTTKPRGK WFCPRCSQER KKK
Target Information
The ING4 gene belongs to the ING (Inhibitor of Growth) family of tumor suppressors. All five members of the ING protein family identified to date contain a highly conserved plant homeodomain (PHD) finger motif at the C-terminal end, which is found in transcription factors that modulate chromatin structure. ING proteins have been shown to form transcriptional complexes leading to activation of responsive genes that mediate a wide range of cellular functions, including growth arrest, DNA repair, gene transcription, apoptosis, and senescence. The candidate tumor suppressor ING4 has a role in brain tumor pathogenesis, and is involved in regulating tumor growth and angiogenesis. Expression of ING4 is reduced in gliomas compared to normal brain tissue, and ING4 reduction correlates with progression from lower to higher grades of tumors. ING4 physically interacts with the p65 (RelA) subunit of NF-kB and represses transcription of NF-kB responsive genes. Inactivating mutations in ING4 transcripts have been described in various human cancer cell lines, and deletion of the ING4 locus has been detected in 10-20% of human breast cancer cell lines and tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain my036 protein; candidate tumor suppressor p33 ING1 homolog; ING1-like protein; Inhibitor of growth protein 4; p29ING4
Gene Aliases: D6Wsu147e; D6Xrf92; ING4; My036; p29ING4
UniProt ID: (Human) Q9UNL4, (Mouse) Q8C0D7
Entrez Gene ID: (Human) 51147, (Rat) 297597, (Mouse) 28019
DNA replication
protein acetylation
apoptotic process
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
cell cycle arrest
negative regulation of cell proliferation
chromatin modification
positive regulation of apoptotic process
histone H3 acetylation
histone H4-K5 acetylation
histone H4-K8 acetylation
histone H4-K12 acetylation
histone H4-K16 acetylation
negative regulation of transcription, DNA-templated
negative regulation of growth
cell cycle
histone acetylation
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