Proteintech

ING5 Polyclonal Antibody

ING5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ING5 Antibody (10665-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer using 10665-1-AP (ING5 antibody) at dilution of 1:100 (under 25x lens).

ING5 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10665-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 20 publications 20 publications

Immunohistochemistry (IHC)

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ING5 Fusion Protein Ag1059 (1-226 aa encoded by BC005370)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MATAMYLEH YLDSIENLPC ELQRNFQLMR ELDQRTEDKK AEIDILAAEY ISTVKTLSPD QRVERLQKIQ NAYSKCKEYS DDKVQLAMQT YEMVDKHIRR LDADLARFEA DLKDKMEGSD FESSGGRGLK KGRGQKEKRG SRGRGRRTSE EDTPKKKKHK GGSEFTDTIL SVHPSDVLDM PVDPNEPTYC LCHQVSYGEM IGCDNPDCPI EWFHFACVDL TTKPKGK (1-226 aa encoded by BC005370)

Target Information

ING5 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Transcriptional Regulation of ING5 and its Suppressive Effects on Gastric Cancer.

Frontiers in oncology

Zheng HC,Xue H,Wu X,Xu HL,Zhao EH,Cui ZG

Sat Jul 16 00:00:00 UTC 2022

SCF^JFK is functionally linked to obesity and metabolic syndrome.

EMBO reports

He L,Yan R,Yang Z,Zhang Y,Liu X,Yang J,Liu X,Liu X,Xia L,Wang Y,Wu J,Wu X,Shan L,Yang X,Liang J,Shang Y,Sun L

Mon Jul 05 00:00:00 UTC 2021

LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration.

Cell research

Wu Y,Zhou L,Liu H,Duan R,Zhou H,Zhang F,He X,Lu D,Xiong K,Xiong M,Zhuang J,Liu Y,Li L,Liang D,Chen YH

Thu Apr 01 00:00:00 UTC 2021

ING5 inhibits cancer aggressiveness by inhibiting Akt and activating p53 in prostate cancer.

Cell biology international

Barlak N,Capik O,Sanli F,Kilic A,Aytatli A,Yazici A,Ortucu S,Ittmann M,Karatas OF

Wed Jan 01 00:00:00 UTC 2020

The Roles of Beclin 1 Expression in Gastric Cancer: A Marker for Carcinogenesis, Aggressive Behaviors and Favorable Prognosis, and a Target of Gene Therapy.

Frontiers in oncology

Zheng HC,Zhao S,Xue H,Zhao EH,Jiang HM,Hao CL

Tue Jan 12 00:00:00 UTC 2021

MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes.

Experimental cell research

Matsuura K,Tani N,Usuki S,Torikai-Nishikawa S,Okano M,Niwa H

Sun Nov 01 00:00:00 UTC 2020

MicroRNA-196b-5p promotes malignant progression of colorectal cancer by targeting ING5.

Cancer cell international

Xin H,Wang C,Chi Y,Liu Z

Thu Apr 14 00:00:00 UTC 2022

ING5 inhibits lung cancer invasion and epithelial-mesenchymal transition by inhibiting the WNT/β-catenin pathway.

Thoracic cancer

Liu XL,Meng J,Zhang XT,Liang XH,Zhang F,Zhao GR,Zhang T

Mon Apr 01 00:00:00 UTC 2019

ING5 differentially regulates protein lysine acetylation and promotes p300 autoacetylation.

Oncotarget

Zhang T,Meng J,Liu X,Zhang X,Peng X,Cheng Z,Zhang F

Fri Jan 05 00:00:00 UTC 2018

ING5 differentially regulates protein lysine acetylation and promotes p300 autoacetylation.

Oncotarget

Zhang T,Meng J,Liu X,Zhang X,Peng X,Cheng Z,Zhang F

Fri Jan 05 00:00:00 UTC 2018

ING5 knockdown enhances migration and invasion of lung cancer cells by inducing EMT via EGFR/PI3K/Akt and IL-6/STAT3 signaling pathways.

Oncotarget

Liu XL,Zhang XT,Meng J,Zhang HF,Zhao Y,Li C,Sun Y,Mei QB,Zhang F,Zhang T

Tue Aug 15 00:00:00 UTC 2017

The nucleocytoplasmic translocation and up-regulation of ING5 protein in breast cancer: a potential target for gene therapy.

Oncotarget

Ding XQ,Zhao S,Yang L,Zhao X,Zhao GF,Zhao SP,Li ZJ,Zheng HC

Tue Oct 10 00:00:00 UTC 2017

The roles of ING5 expression in ovarian carcinogenesis and subsequent progression: a target of gene therapy.

Oncotarget

Zheng HC,Zhao S,Song Y,Ding XQ

Tue Nov 28 00:00:00 UTC 2017

The roles of ING5 expression in ovarian carcinogenesis and subsequent progression: a target of gene therapy.

Oncotarget

Zheng HC,Zhao S,Song Y,Ding XQ

Tue Nov 28 00:00:00 UTC 2017

ING5 suppresses breast cancer progression and is regulated by miR-24.

Molecular cancer

Cui S,Liao X,Ye C,Yin X,Liu M,Hong Y,Yu M,Liu Y,Liang H,Zhang CY,Chen X

Wed May 10 00:00:00 UTC 2017

ING5 suppresses breast cancer progression and is regulated by miR-24.

Molecular cancer

Cui S,Liao X,Ye C,Yin X,Liu M,Hong Y,Yu M,Liu Y,Liang H,Zhang CY,Chen X

Wed May 10 00:00:00 UTC 2017

The roles of ING5 in gliomas: a good marker for tumorigenesis and a potential target for gene therapy.

Oncotarget

Zhao S,Zhao ZJ,He HY,Wu JC,Ding XQ,Yang L,Jia N,Li ZJ,Zheng HC

Tue Aug 22 00:00:00 UTC 2017

Identification of Epigenetic Factor Proteins Expressed in Human Embryonic Stem Cell-Derived Trophoblasts and in Human Placental Trophoblasts.

Journal of proteome research

Sarkar P,Mischler A,Randall SM,Collier TS,Dorman KF,Boggess KA,Muddiman DC,Rao BM

Fri Aug 05 00:00:00 UTC 2016

Identification of Epigenetic Factor Proteins Expressed in Human Embryonic Stem Cell-Derived Trophoblasts and in Human Placental Trophoblasts.

Journal of proteome research

Sarkar P,Mischler A,Randall SM,Collier TS,Dorman KF,Boggess KA,Muddiman DC,Rao BM

Fri Aug 05 00:00:00 UTC 2016

Identification of Epigenetic Factor Proteins Expressed in Human Embryonic Stem Cell-Derived Trophoblasts and in Human Placental Trophoblasts.

Journal of proteome research

Sarkar P,Mischler A,Randall SM,Collier TS,Dorman KF,Boggess KA,Muddiman DC,Rao BM

Fri Aug 05 00:00:00 UTC 2016

MiR-193a-3p promotes the multi-chemoresistance of bladder cancer by targeting the HOXC9 gene.

Cancer letters

Lv L,Li Y,Deng H,Zhang C,Pu Y,Qian L,Xiao J,Zhao W,Liu Q,Zhang D,Wang Y,Zhang H,He Y,Zhu J

Sun Feb 01 00:00:00 UTC 2015

MiR-193a-3p promotes the multi-chemoresistance of bladder cancer by targeting the HOXC9 gene.

Cancer letters

Lv L,Li Y,Deng H,Zhang C,Pu Y,Qian L,Xiao J,Zhao W,Liu Q,Zhang D,Wang Y,Zhang H,He Y,Zhu J

Sun Feb 01 00:00:00 UTC 2015

ING5 inhibits cancer aggressiveness via preventing EMT and is a potential prognostic biomarker for lung cancer.

Oncotarget

Zhang F,Zhang X,Meng J,Zhao Y,Liu X,Liu Y,Wang Y,Li Y,Sun Y,Wang Z,Mei Q,Zhang T

Tue Jun 30 00:00:00 UTC 2015

ING5 inhibits cancer aggressiveness via preventing EMT and is a potential prognostic biomarker for lung cancer.

Oncotarget

Zhang F,Zhang X,Meng J,Zhao Y,Liu X,Liu Y,Wang Y,Li Y,Sun Y,Wang Z,Mei Q,Zhang T

Tue Jun 30 00:00:00 UTC 2015

The miR-193a-3p-regulated ING5 gene activates the DNA damage response pathway and inhibits multi-chemoresistance in bladder cancer.

Oncotarget

Li Y,Deng H,Lv L,Zhang C,Qian L,Xiao J,Zhao W,Liu Q,Zhang D,Wang Y,Yan J,Zhang H,He Y,Zhu J

Thu Apr 30 00:00:00 UTC 2015

The miR-193a-3p-regulated ING5 gene activates the DNA damage response pathway and inhibits multi-chemoresistance in bladder cancer.

Oncotarget

Li Y,Deng H,Lv L,Zhang C,Qian L,Xiao J,Zhao W,Liu Q,Zhang D,Wang Y,Yan J,Zhang H,He Y,Zhu J

Thu Apr 30 00:00:00 UTC 2015

ING5 suppresses proliferation, apoptosis, migration and invasion, and induces autophagy and differentiation of gastric cancer cells: a good marker for carcinogenesis and subsequent progression.

Oncotarget

Gou WF,Shen DF,Yang XF,Zhao S,Liu YP,Sun HZ,Su RJ,Luo JS,Zheng HC

Fri Aug 14 00:00:00 UTC 2015

ING5 suppresses proliferation, apoptosis, migration and invasion, and induces autophagy and differentiation of gastric cancer cells: a good marker for carcinogenesis and subsequent progression.

Oncotarget

Gou WF,Shen DF,Yang XF,Zhao S,Liu YP,Sun HZ,Su RJ,Luo JS,Zheng HC

Fri Aug 14 00:00:00 UTC 2015

Upregulated in Hepatitis B virus-associated hepatocellular carcinoma cells, miR-331-3p promotes proliferation of hepatocellular carcinoma cells by targeting ING5.

Oncotarget

Cao Y,Chen J,Wang D,Peng H,Tan X,Xiong D,Huang A,Tang H

Tue Nov 10 00:00:00 UTC 2015

Upregulated in Hepatitis B virus-associated hepatocellular carcinoma cells, miR-331-3p promotes proliferation of hepatocellular carcinoma cells by targeting ING5.

Oncotarget

Cao Y,Chen J,Wang D,Peng H,Tan X,Xiong D,Huang A,Tang H

Tue Nov 10 00:00:00 UTC 2015

Upregulated in Hepatitis B virus-associated hepatocellular carcinoma cells, miR-331-3p promotes proliferation of hepatocellular carcinoma cells by targeting ING5.

Oncotarget

Cao Y,Chen J,Wang D,Peng H,Tan X,Xiong D,Huang A,Tang H

Tue Nov 10 00:00:00 UTC 2015

Upregulated in Hepatitis B virus-associated hepatocellular carcinoma cells, miR-331-3p promotes proliferation of hepatocellular carcinoma cells by targeting ING5.

Oncotarget

Cao Y,Chen J,Wang D,Peng H,Tan X,Xiong D,Huang A,Tang H

Tue Nov 10 00:00:00 UTC 2015

A targeted RNA interference screen reveals novel epigenetic factors that regulate herpesviral gene expression.

mBio

Oh HS,Bryant KF,Nieland TJ,Mazumder A,Bagul M,Bathe M,Root DE,Knipe DM

Tue Feb 04 00:00:00 UTC 2014

A targeted RNA interference screen reveals novel epigenetic factors that regulate herpesviral gene expression.

mBio

Oh HS,Bryant KF,Nieland TJ,Mazumder A,Bagul M,Bathe M,Root DE,Knipe DM

Tue Feb 04 00:00:00 UTC 2014

Aberrant expression miR-196a is associated with abnormal apoptosis, invasion, and proliferation of pancreatic cancer cells.

Pancreas

Liu M,Du Y,Gao J,Liu J,Kong X,Gong Y,Li Z,Wu H,Chen H

Tue Oct 01 00:00:00 UTC 2013

Aberrant expression miR-196a is associated with abnormal apoptosis, invasion, and proliferation of pancreatic cancer cells.

Pancreas

Liu M,Du Y,Gao J,Liu J,Kong X,Gong Y,Li Z,Wu H,Chen H

Tue Oct 01 00:00:00 UTC 2013

Aberrant expression miR-196a is associated with abnormal apoptosis, invasion, and proliferation of pancreatic cancer cells.

Pancreas

Liu M,Du Y,Gao J,Liu J,Kong X,Gong Y,Li Z,Wu H,Chen H

Tue Oct 01 00:00:00 UTC 2013

Aberrant expression miR-196a is associated with abnormal apoptosis, invasion, and proliferation of pancreatic cancer cells.

Pancreas

Liu M,Du Y,Gao J,Liu J,Kong X,Gong Y,Li Z,Wu H,Chen H

Tue Oct 01 00:00:00 UTC 2013

MicroRNA-193 pro-proliferation effects for bone mesenchymal stem cells after low-level laser irradiation treatment through inhibitor of growth family, member 5.

Stem cells and development

Wang J,Huang W,Wu Y,Hou J,Nie Y,Gu H,Li J,Hu S,Zhang H

Sat Sep 01 00:00:00 UTC 2012

MicroRNA-193 pro-proliferation effects for bone mesenchymal stem cells after low-level laser irradiation treatment through inhibitor of growth family, member 5.

Stem cells and development

Wang J,Huang W,Wu Y,Hou J,Nie Y,Gu H,Li J,Hu S,Zhang H

Sat Sep 01 00:00:00 UTC 2012

The altered expression of ING5 protein is involved in gastric carcinogenesis and subsequent progression.

Human pathology

Xing YN,Yang X,Xu XY,Zheng Y,Xu HM,Takano Y,Zheng HC

Sat Jan 01 00:00:00 UTC 2011

The altered expression of ING5 protein is involved in gastric carcinogenesis and subsequent progression.

Human pathology

Xing YN,Yang X,Xu XY,Zheng Y,Xu HM,Takano Y,Zheng HC

Sat Jan 01 00:00:00 UTC 2011

The altered expression of ING5 protein is involved in gastric carcinogenesis and subsequent progression.

Human pathology

Xing YN,Yang X,Xu XY,Zheng Y,Xu HM,Takano Y,Zheng HC

Sat Jan 01 00:00:00 UTC 2011

The altered expression of ING5 protein is involved in gastric carcinogenesis and subsequent progression.

Human pathology

Xing YN,Yang X,Xu XY,Zheng Y,Xu HM,Takano Y,Zheng HC

Sat Jan 01 00:00:00 UTC 2011

The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas.

Human pathology

Zheng HC,Xia P,Xu XY,Takahashi H,Takano Y

Tue Mar 01 00:00:00 UTC 2011

The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas.

Human pathology

Zheng HC,Xia P,Xu XY,Takahashi H,Takano Y

Tue Mar 01 00:00:00 UTC 2011

The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas.

Human pathology

Zheng HC,Xia P,Xu XY,Takahashi H,Takano Y

Tue Mar 01 00:00:00 UTC 2011

The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas.

Human pathology

Zheng HC,Xia P,Xu XY,Takahashi H,Takano Y

Tue Mar 01 00:00:00 UTC 2011

Decreased nuclear expression and increased cytoplasmic expression of ING5 may be linked to tumorigenesis and progression in human head and neck squamous cell carcinoma.

Journal of cancer research and clinical oncology