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Invitrogen
ING5 Polyclonal Antibody
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Product Details
PA5-100900
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ING5(Accession Q8WYH8), corresponding to amino acid residues D101-D151.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2850395
Product Specific Information
Antibody detects endogenous levels of total ING5.
Target Information
ING5 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: inhibitor of growth family, member 5; Inhibitor of growth protein 5; p28ING5
Gene Aliases: 1700001C14Rik; 1700027H23Rik; 1810018M11Rik; AI225768; ING5; p28ING5
UniProt ID: (Human) Q8WYH8, (Mouse) Q9D8Y8
Entrez Gene ID: (Human) 84289, (Rat) 363292, (Mouse) 66262
DNA replication
protein acetylation
negative regulation of cell proliferation
histone acetylation
positive regulation of apoptotic process
histone H3 acetylation
positive regulation of transcription, DNA-templated
negative regulation of growth
positive regulation of apoptotic signaling pathway
transcription, DNA-templated
chromatin modification
regulation of signal transduction by p53 class mediator
regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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