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Product Details
H00003623-M08
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
3B7
Immunogen
INHA (AAH06391.1, 1 a.a. approximately 366 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MVLHLLLFLL LTPQGGHSCQ GLELARELVL AKVRALFLDA LGPPAVTREG GDPGVRRLPR RHALGGFTHR GSEPEEEEDV SQAILFPATD ASCEDKSAAR GLAQEAEEGL FRYMFRPSQH TRSRQVTSAQ LWFHTGLDRQ GTAASNSSEP LLGLLALSPG GPVAVPMSLG HAPPHWAVLH LATSALSLLT HPVLVLLLRC PLCTCSARPE ATPFLVAHTR TRPPSGGERA RRSTPLMSWP WSPSALRLLQ RPPEEPAAHA NCHRVALNIS FQELGWERWI VYPPSFIFHY CHGGCGLHIP PNLSLPVPGA PPTPAQPYSL LPGAQPCCAA LPGTMRPLHV RTTSDGGYSF KYETVPNLLT QHCACI
Target Information
The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A inhibin subunit; A-inhibin subunit; IHA; inhibin; Inhibin alpha chain
Gene Aliases: INHA
UniProt ID: (Human) P05111
Entrez Gene ID: (Human) 3623
skeletal system development
ovarian follicle development
cell cycle arrest
signal transduction
cell surface receptor signaling pathway
cell-cell signaling
nervous system development
male gonad development
response to external stimulus
positive regulation of pathway-restricted SMAD protein phosphorylation
cell differentiation
erythrocyte differentiation
regulation of cell proliferation
negative regulation of phosphorylation
hemoglobin biosynthetic process
regulation of apoptotic process
regulation of MAPK cascade
negative regulation of interferon-gamma biosynthetic process
negative regulation of B cell differentiation
negative regulation of macrophage differentiation
negative regulation of cell cycle
positive regulation of follicle-stimulating hormone secretion
negative regulation of follicle-stimulating hormone secretion
cell development
regulation of cell cycle
SMAD protein signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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