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Invitrogen
INHBB Polyclonal Antibody
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INHBB Antibody (PA5-28814) in IHC (P)
INHBB Polyclonal Antibody detects Inhibin beta B protein at cytoplasm on human normal kidney by immunohistochemical analysis. Sample: Paraffin-embedded human normal kidney. INHBB Polyclonal Antibody (Product # PA5-28814) diluted at 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-28814
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Inhibin beta B. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2546290
Product Specific Information
Recommended positive controls: A431, H1299.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (100%), Pig (100%), Chicken (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: activin AB beta polypeptide; Activin beta-B chain; Inhibin beta B chain; inhibin, beta B; Inhibin, beta-2
Gene Aliases: INHBB
UniProt ID: (Human) P09529, (Mouse) Q04999
Entrez Gene ID: (Human) 3625, (Mouse) 16324
ovarian follicle development
defense response
cellular response to starvation
response to mechanical stimulus
positive regulation of pathway-restricted SMAD protein phosphorylation
cell differentiation
cellular response to insulin stimulus
activin receptor signaling pathway
growth
regulation of apoptotic process
regulation of MAPK cascade
cellular response to leptin stimulus
fat cell differentiation
negative regulation of insulin secretion
positive regulation of follicle-stimulating hormone secretion
negative regulation of follicle-stimulating hormone secretion
negative regulation of hepatocyte growth factor biosynthetic process
cell development
oocyte development
positive regulation of ovulation
SMAD protein signal transduction
positive regulation of apoptotic signaling pathway
eye development
cellular response to cholesterol
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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