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Invitrogen
INHBB Polyclonal Antibody
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Product Details
PA5-50818
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide of human inhibin, beta B
Conjugate
Form
Liquid
Concentration
2.9 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2636270
Product Specific Information
The antibody detects endogenous levels of total INHBB protein.
Target Information
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: activin AB beta polypeptide; Activin beta-B chain; activin betaB; Inhibin beta B chain; inhibin beta subunit B; inhibin, beta B; Inhibin, beta-2
Gene Aliases: INHBB
UniProt ID: (Human) P09529, (Mouse) Q04999, (Rat) P17491
Entrez Gene ID: (Human) 3625, (Mouse) 16324, (Rat) 25196
ovarian follicle development
defense response
cellular response to starvation
response to mechanical stimulus
positive regulation of pathway-restricted SMAD protein phosphorylation
cell differentiation
cellular response to insulin stimulus
activin receptor signaling pathway
growth
regulation of apoptotic process
regulation of MAPK cascade
cellular response to leptin stimulus
fat cell differentiation
negative regulation of insulin secretion
positive regulation of follicle-stimulating hormone secretion
negative regulation of follicle-stimulating hormone secretion
negative regulation of hepatocyte growth factor biosynthetic process
cell development
oocyte development
positive regulation of ovulation
SMAD protein signal transduction
positive regulation of apoptotic signaling pathway
eye development
cellular response to cholesterol
spermatogenesis
male gonad development
response to organic cyclic compound
response to insecticide
pituitary gland development
response to gonadotropin
cellular response to cAMP
cellular response to interleukin-1
cellular response to organic cyclic compound
cellular response to thyroid hormone stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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