Proteintech

INO80 Polyclonal Antibody

INO80 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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INO80 Antibody (18810-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using (Product # 18810-1-AP) (INO80 antibody) at dilution of 1:150 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

18810-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 14 publications 14 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:150

Immunocytochemistry (ICC/IF)

Assay-dependent

View 4 publications 4 publications

Immunoprecipitation (IP)

View 2 publications 2 publications

ChIP assay (ChIP)

Assay-dependent

View 4 publications 4 publications

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Target Information

DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair.

Science advances

Nguyen DD,Kim E,Le NT,Ding X,Jaiswal RK,Kostlan RJ,Nguyen TNT,Shiva O,Le MT,Chai W

Wed May 10 00:00:00 UTC 2023

Cohesin-independent STAG proteins interact with RNA and R-loops and promote complex loading.

eLife

Porter H,Li Y,Neguembor MV,Beltran M,Varsally W,Martin L,Cornejo MT,Pezić D,Bhamra A,Surinova S,Jenner RG,Cosma MP,Hadjur S

Mon Apr 03 00:00:00 UTC 2023

The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors.

Nature communications

Wang H,Li B,Zuo L,Wang B,Yan Y,Tian K,Zhou R,Wang C,Chen X,Jiang Y,Zheng H,Qin F,Zhang B,Yu Y,Liu CP,Xu Y,Gao J,Qi Z,Deng W,Ji X

Wed Sep 28 00:00:00 UTC 2022

The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors.

Nature communications

Wang H,Li B,Zuo L,Wang B,Yan Y,Tian K,Zhou R,Wang C,Chen X,Jiang Y,Zheng H,Qin F,Zhang B,Yu Y,Liu CP,Xu Y,Gao J,Qi Z,Deng W,Ji X

Wed Sep 28 00:00:00 UTC 2022

Photobiomodulation Drives MiR-136-5p Expression to Promote Injury Repair after Myocardial Infarction.

International journal of biological sciences

Gao X,Li H,Zhang W,Wang X,Sun H,Cao Y,Zhao Y,Ji H,Yang F,Ma W,Liu Y,Yang B,Cai B

Thu May 12 00:00:00 UTC 2022

HIRA complex presets transcriptional potential through coordinating depositions of the histone variants H3.3 and H2A.Z on the poised genes in mESCs.

Nucleic acids research

Yang Y,Zhang L,Xiong C,Chen J,Wang L,Wen Z,Yu J,Chen P,Xu Y,Jin J,Cai Y,Li G

Tue Jan 11 00:00:00 UTC 2022

HIRA complex presets transcriptional potential through coordinating depositions of the histone variants H3.3 and H2A.Z on the poised genes in mESCs.

Nucleic acids research

Yang Y,Zhang L,Xiong C,Chen J,Wang L,Wen Z,Yu J,Chen P,Xu Y,Jin J,Cai Y,Li G

Tue Jan 11 00:00:00 UTC 2022

LINC00839 promotes colorectal cancer progression by recruiting RUVBL1/Tip60 complexes to activate NRF1.

EMBO reports

Liu X,Chen J,Zhang S,Liu X,Long X,Lan J,Zhou M,Zheng L,Zhou J

Mon Sep 05 00:00:00 UTC 2022

INO80 participates in the pathogenesis of recurrent miscarriage by epigenetically regulating trophoblast migration and invasion.

Journal of cellular and molecular medicine

Xian S,Zhang Y,Wang L,Yao F,Ding J,Wang Y,Yang X,Dai F,Yin T,Cheng Y

Thu Apr 01 00:00:00 UTC 2021

INO80 participates in the pathogenesis of recurrent miscarriage by epigenetically regulating trophoblast migration and invasion.

Journal of cellular and molecular medicine

Xian S,Zhang Y,Wang L,Yao F,Ding J,Wang Y,Yang X,Dai F,Yin T,Cheng Y

Thu Apr 01 00:00:00 UTC 2021

Mammalian SWI/SNF continuously restores local accessibility to chromatin.

Nature genetics

Iurlaro M,Stadler MB,Masoni F,Jagani Z,Galli GG,Schübeler D

Mon Mar 01 00:00:00 UTC 2021

Nascent RNA antagonizes the interaction of a set of regulatory proteins with chromatin.

Molecular cell

Skalska L,Begley V,Beltran M,Lukauskas S,Khandelwal G,Faull P,Bhamra A,Tavares M,Wellman R,Tvardovskiy A,Foster BM,Ruiz de Los Mozos I,Herrero J,Surinova S,Snijders AP,Bartke T,Jenner RG

Thu Jul 15 00:00:00 UTC 2021

Linc-MYH configures INO80 to regulate muscle stem cell numbers and skeletal muscle hypertrophy.

The EMBO journal

Schutt C,Hallmann A,Hachim S,Klockner I,Valussi M,Atzberger A,Graumann J,Braun T,Boettger T

Mon Nov 16 00:00:00 UTC 2020

Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability.

Nature communications

Prendergast L,McClurg UL,Hristova R,Berlinguer-Palmini R,Greener S,Veitch K,Hernandez I,Pasero P,Rico D,Higgins JMG,Gospodinov A,Papamichos-Chronakis M

Thu Sep 10 00:00:00 UTC 2020

Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability.

Nature communications

Prendergast L,McClurg UL,Hristova R,Berlinguer-Palmini R,Greener S,Veitch K,Hernandez I,Pasero P,Rico D,Higgins JMG,Gospodinov A,Papamichos-Chronakis M

Thu Sep 10 00:00:00 UTC 2020

BZLF1 interacts with chromatin remodelers promoting escape from latent infections with EBV.

Life science alliance

Schaeffner M,Mrozek-Gorska P,Buschle A,Woellmer A,Tagawa T,Cernilogar FM,Schotta G,Krietenstein N,Lieleg C,Korber P,Hammerschmidt W

Mon Apr 01 00:00:00 UTC 2019

Mot1, Ino80C, and NC2 Function Coordinately to Regulate Pervasive Transcription in Yeast and Mammals.

Molecular cell

Xue Y,Pradhan SK,Sun F,Chronis C,Tran N,Su T,Van C,Vashisht A,Wohlschlegel J,Peterson CL,Timmers HTM,Kurdistani SK,Carey MF

Thu Aug 17 00:00:00 UTC 2017

Mot1, Ino80C, and NC2 Function Coordinately to Regulate Pervasive Transcription in Yeast and Mammals.

Molecular cell

Xue Y,Pradhan SK,Sun F,Chronis C,Tran N,Su T,Van C,Vashisht A,Wohlschlegel J,Peterson CL,Timmers HTM,Kurdistani SK,Carey MF

Thu Aug 17 00:00:00 UTC 2017

INO80 is required for oncogenic transcription and tumor growth in non-small cell lung cancer.

Oncogene

Zhang S,Zhou B,Wang L,Li P,Bennett BD,Snyder R,Garantziotis S,Fargo DC,Cox AD,Chen L,Hu G

Wed Mar 01 00:00:00 UTC 2017

INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma.

Genes & development

Zhou B,Wang L,Zhang S,Bennett BD,He F,Zhang Y,Xiong C,Han L,Diao L,Li P,Fargo DC,Cox AD,Hu G

Wed Jun 15 00:00:00 UTC 2016

INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma.

Genes & development

Zhou B,Wang L,Zhang S,Bennett BD,He F,Zhang Y,Xiong C,Han L,Diao L,Li P,Fargo DC,Cox AD,Hu G

Wed Jun 15 00:00:00 UTC 2016

The Mouse INO80 Chromatin-Remodeling Complex Is an Essential Meiotic Factor for Spermatogenesis.

Biology of reproduction

Serber DW,Runge JS,Menon DU,Magnuson T

Fri Jan 01 00:00:00 UTC 2016

Ino80 is essential for proximal-distal axis asymmetry in part by regulating Bmp4 expression.

BMC biology

Qiu Z,Elsayed Z,Peterkin V,Alkatib S,Bennett D,Landry JW

Mon Mar 14 00:00:00 UTC 2016

Ino80 is essential for proximal-distal axis asymmetry in part by regulating Bmp4 expression.

BMC biology

Qiu Z,Elsayed Z,Peterkin V,Alkatib S,Bennett D,Landry JW

Mon Mar 14 00:00:00 UTC 2016

Ino80 promotes cervical cancer tumorigenesis by activating Nanog expression.

Oncotarget

Hu J,Liu J,Chen A,Lyu J,Ai G,Zeng Q,Sun Y,Chen C,Wang J,Qiu J,Wu Y,Cheng J,Shi X,Song L

Tue Nov 01 00:00:00 UTC 2016

Ino80 promotes cervical cancer tumorigenesis by activating Nanog expression.

Oncotarget

Hu J,Liu J,Chen A,Lyu J,Ai G,Zeng Q,Sun Y,Chen C,Wang J,Qiu J,Wu Y,Cheng J,Shi X,Song L

Tue Nov 01 00:00:00 UTC 2016

INO80 facilitates pluripotency gene activation in embryonic stem cell self-renewal, reprogramming, and blastocyst development.

Cell stem cell