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INO80 Polyclonal Antibody

INO80 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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INO80 Antibody (24819-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using (Product # 24819-1-AP) (INO80 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

INO80 Antibody in Immunoprecipitation (IP)

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Product Details

24819-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

INO80 Fusion Protein Ag20309 (1217-1556 aa encoded by BC146785)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KQVTVYRLI CKGTIEERIL QRAKEKSEIQ RMVISGGNFK PDTLKPKEVV SLLLDDEELE KKLRLRQEEK RQQEETNRVK ERKRKREKYA EKKKKEDELD GKRRKEGVNL VIPFVPSADN SNLSADGDDS FISVDSAMPS PFSEISISSE LHTGSIPLDE SSSDMLVIVD DPASSAPQSR ATNSPASITG SVSDTVNGIS IQEMPAAGRG HSARSRGRPK GSGSTAKGAG KGRSRKSTAG SAAAMAGAKA GAAAASAAAY AAYGYNVSKG ISASSPLQTS LVRPAGLADF GPSSASSPLS SPLSKGNNVP GNPKNLHMTS SLAPDSLVRK QGKGTNPSGG R (1217-1556 aa encoded by BC146785)

Target Information

DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy.

Scientific reports

Napoli E,Song G,Panoutsopoulos A,Riyadh MA,Kaushik G,Halmai J,Levenson R,Zarbalis KS,Giulivi C

Fri Jul 27 00:00:00 UTC 2018

Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy.

Scientific reports

Napoli E,Song G,Panoutsopoulos A,Riyadh MA,Kaushik G,Halmai J,Levenson R,Zarbalis KS,Giulivi C

Fri Jul 27 00:00:00 UTC 2018

The chromatin remodeling protein INO80 contributes to the removal of H2A.Z at the p53-binding site of the p21 gene in response to doxorubicin.

The FEBS journal

Ding J,Yu C,Sui Y,Wang L,Yang Y,Wang F,Yao H,Xing F,Liu H,Li Y,Shah JA,Cai Y,Jin J

Sat Sep 01 00:00:00 UTC 2018

INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma.

Genes & development

Zhou B,Wang L,Zhang S,Bennett BD,He F,Zhang Y,Xiong C,Han L,Diao L,Li P,Fargo DC,Cox AD,Hu G

Wed Jun 15 00:00:00 UTC 2016

INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma.

Genes & development

Zhou B,Wang L,Zhang S,Bennett BD,He F,Zhang Y,Xiong C,Han L,Diao L,Li P,Fargo DC,Cox AD,Hu G

Wed Jun 15 00:00:00 UTC 2016

An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex.

The Journal of allergy and clinical immunology

Kracker S,Di Virgilio M,Schwartzentruber J,Cuenin C,Forveille M,Deau MC,McBride KM,Majewski J,Gazumyan A,Seneviratne S,Grimbacher B,Kutukculer N,Herceg Z,Cavazzana M,Jabado N,Nussenzweig MC,Fischer A,Durandy A

Wed Apr 01 00:00:00 UTC 2015

An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex.

The Journal of allergy and clinical immunology

Wed Apr 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Chromatin-remodeling ATPase INO80; DNA helicase-related INO80 complex homolog 1; DNA helicase-related protein INO80; hINO80; homolog of yeast INO80; INO80 complex subunit A; INO80 homolog; putative DNA helicase INO80 complex homolog 1

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Gene Aliases: hINO80; INO80; INO80A; INOC1; KIAA1259

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UniProt ID: (Human) Q9ULG1

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Entrez Gene ID: (Human) 54617

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Function(s)

DNA binding DNA helicase activity actin binding protein binding ATP binding ATPase activity alpha-tubulin binding

Process(es)

mitotic sister chromatid segregation double-strand break repair via homologous recombination double-strand break repair chromatin remodeling transcription, DNA-templated positive regulation of nuclear cell cycle DNA replication positive regulation of cell growth DNA duplex unwinding cellular response to UV positive regulation of transcription from RNA polymerase II promoter spindle assembly cell division UV-damage excision repair cellular response to ionizing radiation regulation of G1/S transition of mitotic cell cycle

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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INO80 Polyclonal Antibody

INO80 Antibody (24819-1-AP) in IHC (P)

Product Details

24819-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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